Jinhua Central Hospital

healthcare 📍 Jinhua, China
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Lidocaine Infusion Publications
6
Lidocaine Infusion Researchers

Lidocaine Infusion Researchers

Chen YL
4 publications • h-index: 1
Chen D
1 publication
He J
1 publication
Zhu Z
1 publication
Zhao D
1 publication
Fu JP
1 publication • h-index: 2

Publications

Effects of perioperative intravenous lidocaine on postoperative recovery quality in thoracoscopic surgery: a systematic review and meta-analysis.

He J, Chen D, Zhu Z, Zhao D
BMC anesthesiology •

Thoracoscopic surgery, while minimally invasive, is associated with significant postoperative pain, nausea and vomiting, and hemodynamic instability, which can impede recovery. Intravenous lidocaine has been proposed as a multimodal analgesic adjunct due to its potential anti-inflammatory and analgesic properties. This meta-analysis aims to evaluate the effects of perioperative intravenous lidocaine on recovery outcomes in patients undergoing thoracoscopic surgery. Following PRISMA guidelines, a systematic search was conducted in seven databases (CNKI, Wanfang, VIP, CBM, PubMed, Embase, Cochrane Library) from their inception to August 2025 for randomized controlled trials (RCTs) comparing intravenous lidocaine versus saline placebo in thoracoscopic surgery. Primary outcomes were postoperative pain scores (VAS/NRS) and incidence of postoperative nausea and vomiting (PONV). Secondary outcomes included postoperative pulmonary complications (PPC), intraoperative fentanyl consumption, postoperative opioid consumption, hemodynamic parameters (MAP, HR), and Quality of Recovery-40 (QoR-40) scores. Meta-analysis was performed using Review Manager 5.4. The study protocol was registered in PROSPERO (ID: CRD420251183680). Fifteen RCTs involving 1103 patients were included. Lidocaine significantly reduced pain scores at all time points (0–48 h), with peak effect at 2 h (MD = -1.68,  < 0.00001). PONV incidence was lower in the lidocaine group (OR: 0.42,  < 0.00001). Although not statistically significant, a trend toward reduced postoperative pulmonary complications was observed (OR: 0.82,  = 0.26). Intraoperative fentanyl consumption (MD: -92.10,  < 0.00001) and postoperative opioid use (MD: -0.64,  = 0.03) were significantly lower in the lidocaine group. Lidocaine also attenuated hemodynamic responses during intubation and extubation (MAP and HR,  < 0.00001) and improved QoR-40 scores (MD: 2.98,  = 0.003). Regarding safety, reported adverse events were minor and transient, but current evidence is insufficient to fully characterize the safety profile due to inconsistent monitoring and reporting across trials. Perioperative intravenous lidocaine enhances recovery after thoracoscopic surgery by improving analgesia, reducing PONV and opioid use, stabilizing hemodynamics, and promoting overall recovery quality. It should be considered within multimodal ERAS protocols. Further standardized RCTs are warranted to optimize dosing and assess long-term benefits. The online version contains supplementary material available at 10.1186/s12871-026-03794-z.

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Effect of Intraoperative Low-Dose Lidocaine Administration on the Consumption of Mivacurium During Gynecological Laparoscopic Surgery: A Prospective Clinical Study.

Fu JP, Zhou YH, Li SX, Yang YJ, Wang Q , et al.
Drug design, development and therapy •

Recent literatures have shown that lidocaine obviously shortened the onset time and reduced the maintenance dose of vecuronium. However, there have been no reports on the use of mivacurium. This study aimed to investigate the effects of lidocaine on the requirement and onset time of mivacurium administration during gynecological laparoscopic surgery. 66 patients scheduled for elective gynecological laparoscopic surgery were randomly assigned to receive an intravenous bolus of 1.5 mg·kg lidocaine followed by a continuous infusion of 2 mg·kg·h or an equivalent volume of placebo. Neuromuscular block was induced with 0.2 mg·kg followed by an infusion of 0.2 mg·kg·h mivacurium. The primary outcome was the onset time of mivacurium. Consumption of mivacurium, extubation time, and postoperative numeric rating scale (NRS) score for pain were recorded. The onset time of mivacurium was significantly shorter in the lidocaine group than in the control group (mean difference -25.0 s, 95% CI -47.8 to -2.3, =0.032). Hourly consumption of mivacurium was lower in the lidocaine group than in the control group (median difference, -0.04 mg·kg·h; 95% CI, -0.08 to -0.01; =0.017). The extubation time was also significantly shorter in the lidocaine group than in the control group (=0.006). The NRS pain score at 6 h and 12 h after surgery was lower in the lidocaine group than in the control group. Intravenously administered lidocaine significantly decreased the requirement of mivacurium, shortened the onset time, accelerated the extubation time, and alleviated pain intensity at 6 h and 12 h after surgery, without increasing adverse events in patients with a low risk of airway difficulty undergoing gynecological laparoscopic surgery. Given the small sample size from a single centre, our result requires further verification.

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