Publications

Erythromelalgia: Pathophysiology and Clinical Treatment Options, a Narrative Review.

Noble RK, Duplechin MO, Anwar AI , et al. · Current pain and headache reports · 2026

Erythromelalgia (EM) is an uncommon, multifaceted neurovascular pain disorder. The distal extremities are typically affected, with symptoms of overwhelming warmth, burning pain, and erythema. There is...

Severe Erythromelalgia Pain Attack in a Young Lebanese Woman Leading to Hospitalization: A Case Report and Literature Review.

Assaad W, El Tarras O, Al Osta S , et al. · Cureus · 2025

Erythromelalgia is a rare neurovascular syndrome characterized by intense, episodic burning pain that primarily affects the feet and hands and, occasionally, the face. Symptoms are often triggered by...

Comparative Efficacy and Tolerability of Treatments for Erythromelalgia: A Systematic Review.

Algarni AS, Alharthi RM, Alqurashi SO , et al. · Medicina (Kaunas, Lithuania) · 2025

: Erythromelalgia (EM) is an uncommon condition marked by recurring redness, intense burning sensations, and elevated limb warmth. This syndrome can be significantly debilitating, and finding effectiv...

[Pain management in children with erythromelalgia: case report].

Bortoli EI, Sakata RK · Brazilian journal of anesthesiology (Elsevier) · 2018

Erythromelalgia is a neuropathic pain syndrome due to an autosomal dominant gene, characterized by erythema, increased skin temperature and burning pain in hands and feet, whose treatment is often uns...

Pain thresholds, supra-threshold pain and lidocaine sensitivity in patients with erythromelalgia, including the I848Tmutation in Na 1.7.

Helås T, Sagafos D, Kleggetveit IP , et al. · European journal of pain (London, England) · 2017

Nociceptive thresholds and supra-threshold pain ratings as well as their reduction upon local injection with lidocaine were compared between healthy subjects and patients with erythromelalgia (EM). Li...

[Erythromelalgia: Diagnosis and therapeutic approach].

Miranda S, Le Besnerais M, Langlois V , et al. · La Revue de medecine interne · 2017

Erythromelalgia is a rare intermittent vascular acrosyndrome characterized by the combination of recurrent burning pain, warmth and redness of the extremities. It is considered in its primary form as...

Lidocaine-medicated plaster for treating acute autonomic and sensory neuropathy with erythromelalgia-like presentations.

Gales A, Chaaban B, Husson H , et al. · Revue neurologique · 2016

Primary erythromelalgia: a review.

Tang Z, Chen Z, Tang B , et al. · Orphanet journal of rare diseases · 2015

Primary erythromelalgia (PE ORPHA90026) is a rare autosomal dominant neuropathy characterized by the combination of recurrent burning pain, warmth and redness of the extremities. The incidence rate of...

Mexiletine as a treatment for primary erythromelalgia: normalization of biophysical properties of mutant L858F NaV 1.7 sodium channels.

Cregg R, Cox JJ, Bennett DL , et al. · British journal of pharmacology · 2014

The non-selective sodium channel inhibitor mexiletine has been found to be effective in several animal models of chronic pain and has become popular in the clinical setting as an orally available alte...

Primary erythromelalgia in a 12-year-old boy: positive response to sodium channel blockers despite negative SCN9A mutations.

Jakob A, Creutzfeldt R, Staszewski O , et al. · Klinische Padiatrie · 2012

Erythromelalgia is a rare disorder characterized by recurrent pain attacks, swelling and redness in the distal extremities. The primary forms of the disorder are caused by mutations in voltage-gated s...

Pediatric erythromelalgia: a retrospective review of 32 cases evaluated at Mayo Clinic over a 37-year period.

Cook-Norris RH, Tollefson MM, Cruz-Inigo AE , et al. · Journal of the American Academy of Dermatology · 2012

Erythromelalgia has not been well characterized in the pediatric population. We sought to review our experience of erythromelalgia in the pediatric age group. We conducted a retrospective review of pa...

Mexiletine-responsive erythromelalgia due to a new Na(v)1.7 mutation showing use-dependent current fall-off.

Choi JS, Zhang L, Dib-Hajj SD , et al. · Experimental neurology · 2009

Inherited erythromelalgia (IEM), characterized by episodic burning pain and erythema of the extremities, is produced by gain-of-function mutations in sodium channel Na(v)1.7, which is preferentially e...

A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity.

Sheets PL, Jackson JO, Waxman SG , et al. · The Journal of physiology · 2007

Mutations in the TTX-sensitive voltage-gated sodium channel subtype Nav1.7 have been implicated in the painful inherited neuropathy, hereditary erythromelalgia. Hereditary erythromelalgia can be diffi...

Defining a treatable cause of erythromelalgia: acute adolescent autoimmune small-fiber axonopathy.

Paticoff J, Valovska A, Nedeljkovic SS , et al. · Anesthesia and analgesia · 2007

Conditions described as "erythromelalgia" and "erythermalgia" are being formally specified by etiological diagnoses that enable the use of disease-modifying as well as symptomatic treatments. We descr...

Lidocaine patch for pain of erythromelalgia: follow-up of 34 patients.

Davis MD, Sandroni P · Archives of dermatology · 2005

Primary erythromelalgia in a child responding to intravenous lidocaine and oral mexiletine treatment.

Nathan A, Rose JB, Guite JW , et al. · Pediatrics · 2005

Erythromelalgia is a rare, chronic, debilitating condition characterized by redness, warmth, and severe burning pain of the distal extremities. The feet are more commonly affected than the hands. Pain...

[Treatment of familial erythermalgia with the association of lidocaine and mexiletine].

Legroux-Crespel E, Sassolas B, Guillet G , et al. · Annales de dermatologie et de venereologie · 2003

Erythermalgia is a rare acrosyndrome characterized by reddening of the skin, local increase heat and pain. The disease is frequently resistant to treatment. Recently, Kuhnert et al. presented very fav...

Lidocaine patch for pain of erythromelalgia.

Davis MD, Sandroni P · Archives of dermatology · 2002

Lidocaine and mexiletine therapy for erythromelalgia.

Kuhnert SM, Phillips WJ, Davis MD · Archives of dermatology · 1999

Refractory Chronic Kidney Disease-Associated Pruritus: Old Remedies and Novel Agents.

Li KC, Smyth B, Brown M , et al. · Kidney medicine · 2026

Refractory chronic kidney disease associated pruritus (CKDaP) has limited therapeutic options, leading to significant distress, profound sleep disturbance, and reduced quality of life. We describe 2 c...

A Novel Electronic Health Record-Integrated Clinical Pathway for Nephrolithiasis: Development and Management Outcomes.

Lokeshwar SD, Choksi AU, Smani S , et al. · Urology practice · 2025

Acute renal colic from nephrolithiasis is a common condition in emergency departments (EDs). Variation in clinical management contributes to unnecessary opioid use, inadequate discharge planning, and...

Multimodal Therapy in Multidrug-Resistant Prostatitis: A Case Report and Review of the Literature.

Renaud E, Nagassar RP, Persaud S · Cureus · 2024

Chronic bacterial prostatitis is generally difficult to treat. It may involve multiple courses of antibiotics and may be difficult to eradicate with high rates of recurrence. We present the case of a...

Magnesium Sulfate Versus Lidocaine as an Adjunct for Renal Colic in the Emergency Department: A Randomized, Double-Blind Controlled Trial.

Toumia M, Sassi S, Dhaoui R , et al. · Annals of emergency medicine · 2024

We wished to determine whether the addition of magnesium sulfate (MgSO) or lidocaine to diclofenac could improve the analgesic efficacy in emergency department (ED) patients with acute renal colic. In...

The role of intravenous lidocaine infusion in enhanced recovery after laparoscopic renal surgeries: A randomized control trial.

Prajapati DJ, Patel M, Patel P , et al. · Journal of anaesthesiology, clinical pharmacology · 2024

Enhanced recovery after surgery (ERAS) has been applied in various laparoscopic procedures. Intravenous lidocaine (IVL) infusion is used for laparoscopic procedures as a part of ERAS protocols. The st...

2023 American Heart Association Focused Update on the Management of Patients With Cardiac Arrest or Life-Threatening Toxicity Due to Poisoning: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.

Lavonas EJ, Akpunonu PD, Arens AM , et al. · Circulation · 2023

In this focused update, the American Heart Association provides updated guidance for resuscitation of patients with cardiac arrest, respiratory arrest, and refractory shock due to poisoning. Based on...

Comparison of continuous intravenous lidocaine versus transversus abdominis plane block for kidney transplant surgery: a randomized, non-inferiority trial.

Hanson NA, Strunk J, Saunders G , et al. · Regional anesthesia and pain medicine · 2021

Transversus abdominis plane (TAP) blocks are associated with an improvement in postoperative analgesia following kidney transplant surgery. However, these blocks carry inherent risk and require a degr...

Treatment for beta-blocker poisoning: a systematic review.

Rotella JA, Greene SL, Koutsogiannis Z , et al. · Clinical toxicology (Philadelphia, Pa.) · 2020

Beta-adrenoreceptor antagonist (beta-blocker) poisoning is a common overdose which can lead to significant morbidity and mortality. To evaluate the effects of treatments for beta-adrenoreceptor antago...

Comparison of intravenous lidocaine/ketorolac combination to either analgesic alone for suspected renal colic pain in the ED.

Motov S, Fassassi C, Drapkin J , et al. · The American journal of emergency medicine · 2020

To compare analgesic efficacy and safety of intravenous lidocaine and ketorolac combination to each analgesic alone for ED patients with suspected renal colic. We conducted a randomized, double-blind...

Evaluation of opioid requirements in the management of renal colic after guideline implementation in the emergency department.

Minhaj FS, Hoang-Nguyen M, Tenney A , et al. · The American journal of emergency medicine · 2020

Evaluate opioid prescribing before and after emergency department (ED) renal colic guideline implementation focused on multi-modal pain management. Retrospective study of ED patients who received anal...

Intravenous Amide Anesthetics to Treat Pain Associated with Renal Colic in the Emergency Department: a Systematic Review.

C Miller AC, Faza C, Castro Bigalli AA , et al. · Archives of academic emergency medicine · 2020

Renal colic affects 12% of the U.S. population, accounting for nearly 1% of emergency department (ED) visits. Current recommendations advocate narcotic-limiting multimodal analgesia regimens. The obje...

Intravenous lidocaine for renal colic in the emergency department (ED).

Makhoul T, Kelly G, Schult RF , et al. · The American journal of emergency medicine · 2019

Intravenous Lidocaine for Intractable Renal Colic Unresponsive to Standard Therapy.

Sin B, Cao J, Yang D , et al. · American journal of therapeutics · 2019

Renal colic is defined as a flank pain radiating to the groin caused by kidney stones in the ureter (urolithiasis). Renal colic is a frequent cause of Emergency Department visits. Most renal colic cas...

Pain management of renal colic in the emergency department with intravenous lidocaine.

Motov S, Drapkin J, Butt M , et al. · The American journal of emergency medicine · 2018

To describe our experience with intravenous lidocaine (IVL) to manage pain of renal colic origin in the emergency department (ED). A retrospective analysis of all patients presenting with pain of rena...

Intravenous lidocaine as adjuvant to general anesthesia in renal surgery.

Nakhli MS, Kahloul M, Guizani T , et al. · The Libyan journal of medicine · 2018

The role of intraoperative intravenous lidocaine infusion has been previously evaluated for pain relief, inflammatory response, and post-operative recovery, particularly in abdominal surgery. The pres...

Comparison of Different Analgesia Drug Regimens for Pain Control During Extracorporeal Shock Wave Lithotripsy for Renal Stones: A Randomized Control Study.

Waqas M, Butt A, Ayaz Khan M , et al. · Cureus · 2017

With the increased use of extracorporeal shock wave lithotripsy (ESWL), the management of urolithiasis has become much convenient for the patients and the health care professionals alike. However, ass...

Intravenous Lidocaine Compared to Fentanyl in Renal Colic Pain Management; a Randomized Clinical Trial.

Motamed H, Maleki Verki M · Emergency (Tehran, Iran) · 2017

Using alpha blockers such as intravenous (IV) lidocaine has been deemed effective in controlling acute pain. Therefore, the current study was designed with the aim of evaluating the efficiency of IV l...

A comparison between intravenous lidocaine and ketamine on acute and chronic pain after open nephrectomy: A prospective, double-blind, randomized, placebo-controlled study.

Jendoubi A, Naceur IB, Bouzouita A , et al. · Saudi journal of anaesthesia · 2017

Recently, there has been increasing interest in the use of analgesic adjuncts such as intravenous (IV) ketamine and lidocaine. To compare the effects of perioperative IV lidocaine and ketamine on morp...

BET 2: Usefulness of IV lidocaine in the treatment of renal colic.

Keller D, Seamon J, Jones JS · Emergency medicine journal : EMJ · 2016

A shortcut review was carried out to establish whether intravenous lidocaine is effective in the management of renal colic. Two studies were directly relevant to the question. The author, date and cou...

Benefits of intravenous lidocaine on post-operative pain and acute rehabilitation after laparoscopic nephrectomy.

Tauzin-Fin P, Bernard O, Sesay M , et al. · Journal of anaesthesiology, clinical pharmacology · 2014

Intravenous (I.V.) lidocaine has analgesic, antihyperalgesic and anti-inflammatory properties and is known to accelerate the return of bowel function after surgery. We evaluated the effects of I.V. li...

Effectiveness of intravenous lidocaine versus intravenous morphine for patients with renal colic in the emergency department.

Soleimanpour H, Hassanzadeh K, Vaezi H , et al. · BMC urology · 2012

Despite the fact that numerous medications have been introduced to treat renal colic, none has been proven to relieve the pain rapidly and thoroughly. In this study, we aimed at comparing the effects...

Parenteral lidocaine for treatment of intractable renal colic: a case series.

Soleimanpour H, Hassanzadeh K, Mohammadi DA , et al. · Journal of medical case reports · 2011

We report a case series of successful treatment of intractable renal colic using parenteral lidocaine. Because of inconsistent responses to standard treatment with opioids and non-steroidal anti-infla...

Wide QRS tachycardia caused by severe hyperkalaemia and digoxin intoxication.

Goranitou G, Stavrianaki D, Babalis D · Acta cardiologica · 2005

We report the case of a 78-year-old woman, with previous narrow QRS atrial fibrillation, who in the presence of mild digoxin intoxication and severe hyperkalaemia, caused by chronic renal failure and...

What are the parameters for predictive selection of patients requiring anesthesia for extracorporeal shockwave lithotripsy?

Weber A, Koehrmann KU, Denig N , et al. · European urology · 1998

Additional anesthesia is required to minimize the tolerable pain level in efficiently performed extracorporeal shockwave lithotripsy (ESWL) with electrohydraulic and electromagnetic sources. In order...

Efficacy and safety of intravenous lidocaine in thyroidectomy: a systematic review and meta-analysis with trial sequential analysis and meta-regression.

Alatefi D, Saeed O, Alkabazi M , et al. · BMC anesthesiology · 2026

Thyroidectomy is a common surgical procedure associated with postoperative pain and postoperative nausea and vomiting (PONV), which may impair early recovery and quality of recovery (QoR). Intravenous...

Intravenous Lidocaine as an Adjunct for Postoperative Recovery After Open Abdominal Surgery: A Systematic Review.

Muntean C, Ardelean MV, Gaborean V , et al. · Journal of clinical medicine · 2026

major open abdominal surgery remains associated with clinically important postoperative pain, delayed gastrointestinal recovery, opioid exposure, and prolonged length of stay. Intravenous lidocaine in...

Rationale and design of the SMILe (Spinal Morphine or Intravenous Lidocaine) study: protocol for a multicentre randomised clinical trial in southern Sweden on whether spinal morphine improves postoperative recovery compared to intravenous lidocaine in patients undergoing robot-assisted upper urinary tract surgery.

Holmberg M, Chew M, Nilsson L , et al. · BMJ open · 2026

Robot-assisted laparoscopic surgical procedures are commonly perceived to result in fast recovery; however, the postoperative course can be challenging for many patients. We have previously found seve...

Effects of perioperative intravenous lidocaine on postoperative recovery quality in thoracoscopic surgery: a systematic review and meta-analysis.

He J, Chen D, Zhu Z , et al. · BMC anesthesiology · 2026

Thoracoscopic surgery, while minimally invasive, is associated with significant postoperative pain, nausea and vomiting, and hemodynamic instability, which can impede recovery. Intravenous lidocaine h...

Lidocaine combined with low-dose esketamine for movement-evoked pain after hepatectomy: a double-blind randomised controlled trial.

Xu Y, Zhou L, Tang Q , et al. · Anaesthesia · 2026

Pain following hepatectomy may delay recovery and increase opioid use. We tested the primary hypothesis that combining lidocaine and low-dose esketamine would reduce movement-evoked pain 24 h after he...

Perioperative Intravenous Lidocaine and Early Biochemical Outcomes After Robotic-Assisted Radical Prostatectomy: A Clinical Study Within the Framework of Perioperative Metabolic-Inflammatory Modulation.

Popa GM, Abu-Awwad SA, Abu-Awwad A , et al. · Metabolites · 2026

The perioperative period in cancer surgery is characterized by transient metabolic and inflammatory perturbations that may influence early postoperative biochemical dynamics. Surgical stress induces i...

Intravenous lidocaine reduces systemic inflammation but not myocardial injury following thoracic surgery for lung cancer: a randomized controlled trial.

Zhang N, Feng D, Wu W , et al. · BMC anesthesiology · 2026

Elevated high-sensitivity troponin T levels shortly after noncardiac surgery are closely linked to myocardial injury, a key factor in 30-day postoperative mortality. Intravenous lidocaine, known for i...

Efficacy and safety of perioperative intravenous lidocaine infusion for chronic postoperative pain.

Zhang Y, Liang S, Yue X , et al. · Chinese medical journal · 2026

Efficacy of perioperative intravenous lidocaine infusion on postoperative recovery and analgesia in patients undergoing video-assisted thoracoscopic surgery: study protocol for a randomised, double-blind, placebo-controlled trial.

Omindo WW, Xiao Z, Wang X , et al. · BMJ open · 2026

Despite the minimally invasive nature of video-assisted thoracoscopic surgery (VATS), moderate-to-severe postoperative pain remains frequent and impairs recovery. Intravenous lidocaine possesses multi...

Evaluation of the Effect of Intravenous Lidocaine on the Systemic Inflammatory Response Associated With Cardiopulmonary Bypass in Valvular and/or Coronary Cardiac Surgery: Protocol for a Double-Blind Randomized Clinical Trial.

Fernández-Martínez A, López Picado A, González-García J , et al. · Journal of cardiothoracic and vascular anesthesia · 2026

To assess whether intravenous lidocaine reduces the systemic inflammatory response associated with cardiopulmonary bypass (CPB) and improves clinical outcomes in adult patients undergoing elective val...

Exploring the Therapeutic Potential of Intravenous Lidocaine: A Narrative Review on Postoperative Pain Management and Opioid Reduction.

Takla J, Milan M, Ibrahim R , et al. · Pain management nursing : official journal of the American Society of Pain Management Nurses · 2026

This study aimed to evaluate the efficacy and safety of intravenous (IV) lidocaine as an alternative analgesic approach in the management of postoperative pain. A PubMed search was conducted using key...

Intravenous Lidocaine for Postoperative Pain in Children Undergoing Tonsillectomies: A Double-Blinded, Randomized, Placebo-Controlled Trial.

Benzon HA, King MR, Kilner KJ , et al. · Anesthesia and analgesia · 2026

Tonsillectomy is a commonly performed surgical procedure in children, and the recovery period can be associated with significant postoperative pain. Currently, there are no studies examining the effic...

The effect of perioperative lidocaine during modified radical mastectomy on postoperative pain and immune response: A randomized clinical trial.

Hadavi SMR, Sahmeddini MA, Khademi S , et al. · Journal of cancer research and therapeutics · 2026

Breast cancer is the most common cancer among women. Surgical resection of the breast mass could induce an inflammatory response, which increases cytokines, such as interleukin IL beta-1 and IL-6. The...

The erector spinae plane block is not superior to perioperative systemic lidocaine infusion for postoperative analgesia management after thoracotomy: a randomized double-blind study.

Küçün T, Ahiskalioglu EO, Yayik AM , et al. · General thoracic and cardiovascular surgery · 2026

The effect of erector spinae plane block and systemic lidocaine infusion for major thoracotomy is still unclear. Therefore, we aimed to compare ESPB, systemic lidocaine and standard analgesia in patie...

Postoperative intravenous lidocaine infusion for pain management in pelvic bone tumor surgery patients: a randomized, double-blind, controlled trial.

Huo F, Zhang R, Wu Y , et al. · Journal of anesthesia, analgesia and critical care · 2026

Previous studies have demonstrated that perioperative use of lidocaine effectively reduces opioid requirements in various surgical procedures. Our objective was to evaluate the effect of postoperative...

Comparison of the effects of dexmedetomidine and lidocaine on postoperative analgesia and recovery characteristics: a meta-analysis of randomized controlled trials.

Hung KC, Chang LC, Wang WT , et al. · Systematic reviews · 2026

Dexmedetomidine and lidocaine are commonly used adjuvants in postoperative pain management; however, their comparative efficacy is unclear. This meta-analysis compared the effects of intravenous dexme...

Intravenous Lidocaine in Video-Assisted Thoracoscopic Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Mamun MA, Saleem Y, El-Tahlawy Y , et al. · Journal of cardiothoracic and vascular anesthesia · 2026

Effective postoperative recovery after video-assisted thoracoscopic surgery (VATS) remains a significant challenge, with patients frequently experiencing moderate to severe pain, pulmonary decline, an...

Intravenous lidocaine for gastrointestinal recovery after colorectal surgery: the ALLEGRO placebo-controlled randomised trial and cost-effectiveness analysis.

Paterson H, Vadiveloo T, Innes K , et al. · Health technology assessment (Winchester, England) · 2026

Delayed return of gut function after colonic resection is a common impediment to early postoperative recovery. Small clinical studies, combined into meta-analyses, have suggested that intravenous lido...

Intravenous lidocaine infusion accelerates postoperative bowel function recovery in patients undergoing lumbar surgery: a multi-center, randomized controlled trial.

Huo F, Zhang R, Wu Y , et al. · International journal of surgery (London, England) · 2026

Lumbar surgery is often associated with significant postoperative pain, high opioid consumption, and delayed bowel function recovery. This study aimed to assess whether intravenous lidocaine infusion...

Treatment heterogeneity in intravenous lidocaine analgesia: implications for pain phenotype-guided therapy.

Hung MH, Cheng SY · Journal of anesthesia, analgesia and critical care · 2026

Analgesic Effects of Intravenous Lidocaine in Laparoscopic Surgery: A Systematic Review and Meta-analysis With Trial Sequential Analysis.

Ng KT, Lim WE, Teoh WY , et al. · The Clinical journal of pain · 2026

Recent studies have showed that intravenous lidocaine is associated with reducing postoperative pain. However, the mechanism of action of intravenous lidocaine as a part of multi-modal analgesic regim...

Premixed Lidocaine With Fospropofol Disodium for Safety and Clinical Evaluation Regarding Paresthesia Upon Fospropofol Disodium Injection: A Preclinical Experimental Study and a Randomized Controlled Trial.

Jiao B, Xu X, Cui Y , et al. · MedComm · 2026

Fospropofol disodium (fospropofol), a water-soluble prodrug of propofol, reduces injection pain and anesthetic requirements but frequently causes paresthesia. Intravenous lidocaine has been shown to a...

Comparison of Erector Spinae Plane Block and Intravenous Lidocaine in Opioid-Free Anesthesia for Laparoscopic Sleeve Gastrectomy: A Randomized Controlled Trial.

Maciejewski P, Skladzien T, Tabin L , et al. · Obesity surgery · 2026

INTRODUCTION: Opioid-free anesthesia (OFA) protocols are increasingly adopted in metabolic and bariatric surgery to minimize opioid-related complications. Both erector spinae plane block (ESPB) and in...

Analgesic efficacy and safety of lidocaine administered by intravenous route vs erector spinae plane blocks following open heart surgery: An open-label, randomized clinical trial.

Selvamani BJ, Sharma A, Farhat B , et al. · Journal of clinical anesthesia · 2026

The erector spinae plane (ESP) block is a widely used regional analgesic technique for truncal analgesia. This randomized, open-label trial compared intravenous (IV) lidocaine to lidocaine administere...

Effect of lidocaine on acute pain after modified radical mastectomy: a secondary analysis of a randomized trial.

Liu J, Zhang W, Li X , et al. · Frontiers in medicine · 2026

Postoperative pain is a common concern for patients undergoing modified radical mastectomy (MRM) for breast cancer. Intravenous lidocaine may alleviate acute postsurgical pain. This study aimed to eva...

Effect of Intraoperative Low-Dose Lidocaine Administration on the Consumption of Mivacurium During Gynecological Laparoscopic Surgery: A Prospective Clinical Study.

Fu JP, Zhou YH, Li SX , et al. · Drug design, development and therapy · 2026

Recent literatures have shown that lidocaine obviously shortened the onset time and reduced the maintenance dose of vecuronium. However, there have been no reports on the use of mivacurium. This study...

Effect of Intraoperative Intravenous Lidocaine on Postoperative Delirium in Elderly Patients Undergoing Posterior Lumbar Interbody Fusion.

Feng X, Jia J, Sang Y , et al. · Drug design, development and therapy · 2026

This study aimed to evaluate the effect of intraoperative intravenous (IV) lidocaine on the incidence of postoperative delirium (POD) in elderly patients undergoing major spinal surgery. In this prosp...

Erratum: Effect of Intraoperative Intravenous Lidocaine on Postoperative Delirium in Elderly Patients Undergoing Posterior Lumbar Interbody Fusion [Corrigendum].

· Drug design, development and therapy · 2026

[This corrects the article DOI: 10.2147/DDDT.S571032.].

Efficacy and safety of lidocaine versus sufentanil in patient-controlled intravenous analgesia after laparoscopic colorectal cancer surgery: a prospective, randomized, double-blind clinical trial.

Wu Y, Tian B, Li L , et al. · BMC anesthesiology · 2025

This study aimed to compare the efficacy and safety of lidocaine-based patient-controlled intravenous analgesia (PCIA) with sufentanil-based PCIA for managing postoperative pain in patients undergoing...

The effect of continuous intravenous lidocaine infusion on postoperative analgesia in elderly patients undergoing laparoscopic colorectal surgery.

Wan Q, Yi Q, Huang R , et al. · BMC anesthesiology · 2025

This study aimed to evaluate the effect of continuous intravenous infusion of different doses of lidocaine on postoperative analgesia in elderly patients undergoing laparoscopic colorectal surgery. In...

Intravenous Lidocaine for Postoperative Pain and Recovery After Robotic Prostate Adenomectomy: A Retrospective Observational Cohort Study.

Popa GM, Abu-Awwad SA, Abu-Awwad A , et al. · Medicina (Kaunas, Lithuania) · 2025

: Effective perioperative pain management remains a key goal of enhanced recovery protocols, especially in minimally invasive urologic surgery, where optimizing comfort while limiting opioid exposure...

Effect of intravenous lidocaine infusion on postoperative pulmonary complications in patients undergoing minimally invasive esophagectomy: a study protocol of double-center, double-blind, randomized controlled trial.

Wang F, Zhang H, Peng X , et al. · Trials · 2025

Esophageal cancer is the eighth most prevalent malignant tumor in the world and has the sixth highest mortality rate. Postoperative pulmonary complications (PPCs) are one of the most common complicati...

Effect of perioperative lidocaine application on inflammatory factors, immune function, and quality of early postoperative recovery in patients undergoing video-assisted thoracoscopic surgery: a randomized controlled trial.

Zhang L, Wei P, Wang H , et al. · European journal of medical research · 2025

To assess the effect of low-dose perioperatively continuous infusion of lidocaine on postoperative inflammation, immune function and quality of recovery in patients undergoing video-assisted thoracosc...

Intravenous Lidocaine Decreases Pain Scores 24 Hours Post Cardiac Surgery: Substudy of a Randomized Controlled Trial.

Klinger R, Strickland A, Wright M , et al. · Pain physician · 2025

Post cardiac surgery pain remains a problem for a significant number of patients. While opioids have long been used for cardiac surgery pain control and hemodynamic stability, methods to improve pain...

Effect of intraoperative paravertebral or intravenous lidocaine infusion on postoperative complications and inflammation after lung resection surgery: a randomised controlled trial.

de la Gala F, de la Fuente E, Piñeiro P , et al. · British journal of anaesthesia · 2025

The potential for the anti-inflammatory effects of lidocaine to reduce complications after lung resection has not been evaluated. We assessed whether intraoperative i.v. or paravertebral lidocaine, co...

Anti-Inflammatory and Immunomodulatory Effects of Intravenous Lidocaine in Surgery: A Narrative Review.

Fernández-Martínez A, García JG, López-Picado A · Journal of clinical medicine · 2025

Lidocaine, a widely used local anaesthetic, has been shown to possess anti-inflammatory and immunomodulatory properties with applications in surgery. During a surgical procedure, inflammation is a nat...

Effect of intravenous lidocaine on postoperative fatigue syndrome in patients undergoing laparoscopic radical colorectal cancer surgery: a randomized clinical trial.

Guo S, Sun B, Wang X , et al. · Scientific reports · 2025

To investigate the effect of intravenous lidocaine on postoperative fatigue syndrome (POFS) in laparoscopic radical colorectal cancer surgery patients, a randomized controlled trial enrolled 86 patien...

Comparison of intraoperative intravenous lidocaine infusion and transversus abdominis plane block for postoperative analgesia following laparoscopic cholecystectomy: a randomized controlled trial.

Sheikh H, Zafar S, Nawaz K , et al. · Anesthesia and pain medicine · 2025

Laparoscopic cholecystectomy has been associated with moderate to severe intensity pain, especially in the early postoperative period. Among pain modalities, the transversus abdominis plane (TAP) bloc...

Combining ropivacaine transversus abdominis plane block with intravenous lidocaine infusion in adults undergoing colorectal cancer surgery: an open-label, dose-escalation exploratory trial.

Zhou M, Yu F, Xu Y , et al. · BMC anesthesiology · 2025

The concurrent use of a ropivacaine transversus abdominis plane (TAP) block with intravenous lidocaine infusion, though effective for pain relief, raises safety concerns regarding local anesthetic sys...

Pharmacokinetics of Intraperitoneal Lidocaine for Sustained Postoperative Analgesia in Adults.

Osborne KW, MacFater WS, Anderson BJ , et al. · European journal of drug metabolism and pharmacokinetics · 2025

Intraperitoneal lidocaine is an emerging strategy for analgesia following abdominal surgery but its pharmacokinetics are poorly quantified. We aimed to develop a pharmacokinetic model for unbound and...

Perioperative Intravenous Lidocaine Infusion Therapy as an Adjunct to Multimodal Analgesia for Adolescent Idiopathic Scoliosis Surgical Correction: A Double-Blind Randomized Controlled Trial.

Luo J, West N, Pang S , et al. · Paediatric anaesthesia · 2025

Posterior spinal instrumentation and fusion is a common surgical correction for adolescent idiopathic scoliosis. Preventative multimodal analgesia, including opioids, is required to minimize postopera...

Perioperative intravenous lidocaine as an analgesic adjunct in adolescent idiopathic scoliosis surgery.

Hasan MS, Selvanathan P, Lee ZY , et al. · Journal of pediatric orthopedics. Part B · 2025

Opioids are the mainstay of pain management in scoliosis surgery. We hypothesized that in adolescent idiopathic scoliosis (AIS) patients undergoing posterior spinal fusion (PSF) surgery, perioperative...

Optimising peri-operative intravenous lidocaine dosing regimens.

Tognolini A, Roberts JA, Eley VA · Anaesthesia · 2025

Impact of intravenous infusion of lidocaine on intrapulmonary shunt and postoperative cognitive function in patients undergoing one-lung ventilation.

Yang D, Yang Q, Wang Y , et al. · Advances in clinical and experimental medicine : official organ Wroclaw Medical University · 2025

Intravenous infusion of lidocaine as an anesthesia adjuvant can improve patient outcomes, but its impact on intrapulmonary shunt during one-lung ventilation (OLV) has not been clarified. To determine...

Intravenous Lidocaine for Gut Function Recovery in Colonic Surgery: A Randomized Clinical Trial.

Paterson H, Vadiveloo T, Innes K , et al. · JAMA · 2025

Despite the recovery advantages of minimally invasive surgical techniques, delayed return of gut function after colectomy is a common barrier to timely discharge from hospital. To evaluate the effect...

Reply to: comparing the efficacy of intravenous lidocaine versus placebo for postoperative analgesia in paediatric patients: methodology is important.

Pardessus P, Dahmani S · European journal of anaesthesiology · 2025

Comparing the efficacy of intravenous lidocaine versus placebo for postoperative analgesia in paediatric patients: Methodology is important.

Sun L, Feng Y · European journal of anaesthesiology · 2025

Effect of Intravenous Lidocaine on Postoperative Cognitive Dysfunction in Patients Undergoing General Anesthesia Surgery: A Systematic Review of a Randomized Controlled Trial.

Wang XX, Dai J, Deng HW , et al. · Clinical therapeutics · 2025

Postoperative cognitive dysfunction (POCD) is a common neurologic complication that occurs after surgery, which prolongs the hospital stay of patients to a certain extent, increases the occurrence of...

Perioperative intravenous lidocaine infusion improves postoperative analgesia after hysterectomy: a systematic review and meta-analysis of randomized controlled trials.

Tang P, Sun Q, Li Z , et al. · International journal of surgery (London, England) · 2025

The effectiveness of intravenous lidocaine in reducing acute pain after hysterectomy remains uncertain. The authors conducted a meta-analysis of randomized controlled trials (RCTs) to investigate the...

The Effect of Intravenous Lidocaine, Ketamine, and Lidocaine-Ketamine Combination in Colorectal Cancer Surgery: A Randomized Controlled Trial.

Ostović H, Šimac B, Pražetina M , et al. · Anesthesia and analgesia · 2025

Colorectal resections are associated with a pronounced inflammatory response, severe postoperative pain, and postoperative ileus. The aim of this study was to evaluate the main effects of lidocaine an...

Intravenous lidocaine infusion therapy and intraoperative neurophysiological monitoring in adolescents undergoing idiopathic scoliosis correction: A retrospective study.

Bates R, Cave F, West N , et al. · Paediatric anaesthesia · 2025

Posterior spinal instrumentation and fusion is an established surgical procedure for the correction of adolescent idiopathic scoliosis. Intraoperative neurophysiological monitoring is standard practic...

Intravenous lidocaine for gut function recovery in colonic surgery: a health economic evaluation of the ALLEGRO randomised clinical trial.

Atter M, Stoddart A, Cotton S , et al. · BMJ open · 2025

To compare costs, health outcomes and cost-effectiveness of using intravenous lidocaine (bolus given at induction of anaesthesia, followed by infusion for 6-12 hours) during colorectal surgery to impr...

The effect of intravenous lidocaine infusion on subarachnoid anesthesia in patients undergoing total knee replacement: a randomised controlled trial.

Kodkani A, Bhalotra AR, Singh R , et al. · Journal of anesthesia · 2025

Intravenous lidocaine is a non-opioid analgesic adjunct for perioperative pain relief. The aim of our study was to explore whether concurrent administration of intravenous lidocaine prolongs the durat...

Comparison of the effects of perioperative intravenous infusions of esmolol and lidocaine on the quality of postoperative recovery in patients undergoing functional endoscopic sinus surgery: a randomized, double-blind, noninferiority study.

Yang H, Wang L, Zhu K , et al. · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025

Perioperative intravenous lidocaine infusion can improve the quality of recovery (QoR) in patients undergoing functional endoscopic sinus surgery (FESS), but the effect of esmolol on recovery has been...

Systemic Anti-Inflammatory and Immunomodulatory Effects of Intravenous Lidocaine During Robotic-Assisted Radical Prostatectomy: A Prospective Observational Study.

Popa GM, Abu-Awwad SA, Abu-Awwad A , et al. · Medicina (Kaunas, Lithuania) · 2025

: Surgical stress during robotic-assisted radical prostatectomy (RARP) elicits a measurable systemic inflammatory response despite the minimally invasive approach. Intravenous lidocaine has been incre...

Comment on "Intravenous lidocaine infusion accelerates postoperative bowel function recovery in patients undergoing lumbar surgery: a multi-center, randomized controlled trial".

Yin X, Peng R, Zhang Y · International journal of surgery (London, England) · 2025

A Potential Role of Intraoperative Lidocaine in Patients Undergoing Thyroidectomy-An Original Systematic Review and Meta-Analysis.

Khan A, Emmama S, Aamir M , et al. · Health science reports · 2025

Thyroidectomy is a routine operation for diverse thyroid diseases between benign and malignant. In such cases, the complications and postoperative pains, such as nausea, vomiting, and hemodynamic inst...

Clarifying the postsurgical persistent pain after laparoscopic cholecystectomy and the role of intravenous lidocaine.

Abreu-Pires M, Cavaleiro C, Machado H , et al. · Pain reports · 2025

Persistent abdominal pain after laparoscopic cholecystectomy (PAPLC) incidence is estimated between 3% and 56%. Data concerning PAPLC intensity and its neuropathic characteristics is scarce, and the r...

Corrigendum to 'Efficacy of prolonged intravenous lidocaine infusion for postoperative movement-evoked pain following hepatectomy' (Br J Anaesth 2023; 131: 113-21).

Xu Y, Ye M, Liu F , et al. · British journal of anaesthesia · 2025

Perioperative plasma lidocaine concentrations and their impact on pain control. A systematic review and meta-analysis.

Foong KW, Lo YL, Chaw SH , et al. · Pain management · 2025

To review the relationship between drug concentrations of perioperative intravenous lidocaine and their analgesic effects. We systematically searched SCOPUS, Medline, EMBASE, CENTRAL, and Web of Scien...

Intravenous lidocaine enhances the efficacy of ondansetron and dexamethasone in postoperative vomiting prophylaxis among high-risk children.

Xu JF, Du MC, Chen Y , et al. · Scientific reports · 2025

A combination of dexamethasone, ondansetron, and total intravenous anaesthesia (TIVA) is recommended as prophylaxis for preventing postoperative vomiting (POV) in high-risk children. Implementing TIVA...

The Postoperative Lidocaine and Ketamine Effects on Morphine Requirement in Bariatric Surgery.

Contreras Pérez G, Frederico Avendaño C, Cortínez LI , et al. · Obesity surgery · 2025

Effective postoperative pain management in patients with obesity undergoing metabolic bariatric surgery is challenging due to the adverse effects associated with opioid use. Multimodal analgesic appro...

Compare the Effects of Transversalis Fascia Plane Block versus Intravenous Lidocaine Infusion on the Quality of Early Postoperative Recovery in Patients Undergoing Gynecologic Laparoscopic Surgery.

Zhang P, Zhao Y, Mu H , et al. · Journal of pain research · 2025

To compare the effects of transversalis fascia plane (TFP) block versus intravenous lidocaine infusion on early recovery after gynecologic laparoscopic surgery. In this randomized trial, 59 patients w...

Impact of transversus abdominis plane block plus intravenous lidocaine on rapid recovery after bariatric surgery.

Wang X, Zhang Y, Guo Q , et al. · Frontiers in medicine · 2025

The study aimed to explore the impact of transversus abdominis plane block (TAPB) combined with intravenous lidocaine on rapid recovery after bariatric surgery. A total of 80 patients who underwent el...

Intravenous Lidocaine and Cognitive Recovery After Endoscopic Submucosal Dissection: A Randomized Controlled Trial.

Liang Y, Qian B, Zhuo Y , et al. · Drug design, development and therapy · 2025

While intravenous lidocaine reduces propofol requirements during procedures, its effects on postoperative cognitive function remain uncertain. This study evaluated whether lidocaine enhances cognitive...

Lidocaine-Based vs Sufentanil-Based PCIA After Pulmonary Resection Surgery: A Randomized Controlled Trial.

Tian B, Wu Y, Zhang W , et al. · Drug design, development and therapy · 2025

We investigated the efficacy and safety of lidocaine-based patient-controlled intravenous analgesia (PCIA), compared with sufentanil-based PCIA on postoperative pain and recovery quality in patients u...

Effect of intravenous lidocaine on nociception level-directed management in robot-assisted laparoscopic radical prostatectomy: protocol for a single-centre, factorial-randomised controlled trial (VALINOR study).

Matsuura H, Tanaka N, Sasaki Y , et al. · Anaesthesia reports · 2025

To evaluate the efficacy of intra-operative lidocaine administration combined with nociception level-guided opioid management and to compare two minimum remifentanil infusion rate limits (0.11 vs. 0.0...

Intravenous lidocaine reduces pain intensity and attenuates the increase in plasma norepinephrine levels after hysterectomy.

Musba AMT, Sardi S, Ratnawati · Qatar medical journal · 2025

Intravenous lidocaine is used to treat acute postoperative pain by reducing discomfort, accelerating mobilization, and shortening hospitalization. This study evaluated the effects of intravenous bolus...

Effect of Intravenous Lidocaine on Postoperative Cognitive Dysfunction in Patients Undergoing Laparoscopic Colorectal Surgery: A Two-Center, Randomized, Double-Blind Controlled Trial.

Liu KP, Dai J, Huang FR , et al. · Current therapeutic research, clinical and experimental · 2025

In patients undergoing gastrointestinal surgery, enhancing perioperative cognitive function and facilitating expedited postoperative recovery are critical components for achieving swift rehabilitation...

Optimizing Lidocaine Dosing in Hepatectomy Patients: A Population Pharmacokinetic Study of Active Metabolites.

He C, Qi X, Liu Y , et al. · Drug design, development and therapy · 2025

Lidocaine and its active metabolites are metabolized mainly by the liver, and liver-compromised may slow the metabolism of lidocaine and its active metabolites. In addition to excessive lidocaine, acc...

Effect of perioperative lidocaine infusion on the subjective quality of recovery after surgery: Protocol for an updated systematic review and meta-analysis.

Huang Q, Shao C, Wei W , et al. · PloS one · 2025

Lidocaine is increasingly used for surgical patients requiring general anesthesia. However, its clinical benefits on postoperative recovery quality are not well established. Our main objective aims to...

The mechanism of perioperative intravenous lidocaine in regulating the inflammatory response: A review.

Wang J, Bian Q, Chen X , et al. · Medicine · 2024

Perioperative inflammatory responses are a series of endogenous immune responses produced by the body following surgical trauma. Excessive inflammatory response weakens the body's ability to repair su...

Impact of Perioperative Lidocaine on Neutrophil Extracellular Trapping and Serum Cytokines in Robot-Assisted Radical Prostatectomy: Randomized Controlled Study.

Shin D, Kim J, Lee S , et al. · Medicina (Kaunas, Lithuania) · 2024

This randomized controlled trial investigated the influence of perioperative lidocaine administration on the postoperative inflammatory response in patients undergoing robot-assisted radical prostatec...

Reply to 'Determining postoperative benefits of intravenous lidocaine and esketamine following thyroidectomy'.

Li M, Yang X, Zhu K , et al. · Indian journal of anaesthesia · 2024

Determining postoperative benefits of intravenous lidocaine and esketamine following thyroidectomy.

Wang DF, Lin DY, Xue FS · Indian journal of anaesthesia · 2024

The effect of perioperative intravenous lidocaine infusion on postoperative sleep of elderly patients with colorectal cancer: A randomized controlled study.

Wang X, Deng L, Wu Y , et al. · Journal of anesthesia and translational medicine · 2024

Postoperative sleep disturbance (POSD) caused by postoperative pain can impede the enhanced rapid recovery of elderly patients with colorectal cancer. We propose that perioperative intravenous lidocai...

Effect of systemic lidocaine infusion on optic nerve sheath diameter during laparoscopic hysterectomy: a randomized controlled study.

Rehab OM, Elsharkawy MS, Bakr DM , et al. · Minerva anestesiologica · 2024

During laparoscopic hysterectomy (LH), the elevation of intra-abdominal and intra-thoracic pressures due to pneumoperitoneum (PP) results in an increase in intracranial pressure (ICP). The Trendelenbu...

Perioperative intravenous lidocaine infusion for postsurgical pain management in bariatric surgery patients.

Duarte-Medrano G, Nuño-Lámbarri N, Dominguez-Franco A , et al. · Journal of anesthesia, analgesia and critical care · 2024

Obesity is one of the biggest modern health issues worldwide. Owing to the failure of both behavioral and pharmacological measures, the surgical approach has been established as the main conduct to fo...

"Can Perioperative Intravenous Lidocaine Decrease Postoperative Pain After Oral and Maxillofacial Surgeries?": A Randomized Clinical Trial.

Mahato VK, Dongol A, Acharya P , et al. · Journal of maxillofacial and oral surgery · 2024

To determine the efficacy of perioperative intravenous lidocaine in decreasing postoperative pain after oral and maxillofacial surgeries. Forty patients undergoing various oral and maxillofacial surge...

Comparing postoperative pain relief: ketorolac and Nasocalcin spray versus lidocaine and Nasocalcin spray in abdominal surgery patients.

Saadat Fakhr M, Qasemi M, Rezvanfar K , et al. · Annals of medicine and surgery (2012) · 2024

Postoperative pain management is critical for patient recovery after abdominal surgery. This study compared intravenous lidocaine and ketorolac for reducing postoperative pain and opioid use, along wi...

Evaluation of intraoperative lidocaine on the prevention of postoperative shoulder pain in gynecologic laparoscopy: A prospective randomized, double-blind, placebo-controlled study.

Zhao L, Li B, Li N , et al. · The journal of obstetrics and gynaecology research · 2024

To assess the effectiveness of intraoperative lidocaine in reducing the incidence of post-laparoscopic shoulder pain (PLSP) after gynecologic laparoscopy. Patients undergoing total laparoscopic hyster...

Systemic lidocaine versus erector spinae plane block for improving quality of recovery after laparoscopic cholecystectomy: A randomized controlled trial.

Lin Z, Chen C, Xie S , et al. · Journal of clinical anesthesia · 2024

To compare intravenous lidocaine, ultrasound-guided erector spinae plane block (ESPB), and placebo on the quality of recovery and analgesia after laparoscopic cholecystectomy. A prospective, triple-ar...

The analgesic effectiveness of perioperative lidocaine infusions for acute and chronic persistent postsurgical pain in patients undergoing breast cancer surgery. Comment on Br J Anaesth 2024; 132: 575-87.

Liu H, Lei X · British journal of anaesthesia · 2024

Perioperative intravenous lidocaine infusion for chronic pain after breast cancer surgery: a trial sequential analysis of the original meta-analysis. Comment on Br J Anaesth 2024; 132: 575-87.

Chen IW, Chang LC, Lin CM , et al. · British journal of anaesthesia · 2024

Intravenous lidocaine for postoperative analgesia management in paediatrics: A systematic review with meta-analysis of published studies.

Pardessus P, Loiselle M, Brouns K , et al. · European journal of anaesthesiology · 2024

The administration of intravenous lidocaine during the peri-operative period may improve pain management after paediatric surgery. To explore the decrease in postoperative pain intensity and opioid co...

Prevention of persistent pain with lidocaine infusions in breast cancer surgery (PLAN): study protocol for a multicenter randomized controlled trial.

Khan JS, Gilron I, Devereaux PJ , et al. · Trials · 2024

Persistent pain is a common yet debilitating complication after breast cancer surgery. Given the pervasive effects of this pain disorder on the patient and healthcare system, post-mastectomy pain synd...

Effect of lidocaine on intraoperative blood pressure variability in patients undergoing major vascular surgery.

Gajniak D, Mendrala K, König-Widuch G , et al. · BMC anesthesiology · 2024

Dynamic fluctuations of arterial blood pressure known as blood pressure variability (BPV) may have short and long-term undesirable consequences. During surgical procedures blood pressure is usually me...

Effects of intravenous single-bolus lidocaine infusion versus intravenous single-bolus magnesium sulfate infusion on postoperative pain, emotional status, and quality of life in patients undergoing spine fusion surgery: a randomized study.

Abdel Rady MM, Osman AM, Abo Elfadl GM , et al. · Minerva anestesiologica · 2024

We assessed the efficiency of intravenous adjuvants in decreasing opioid intake and pain scores after spine fusion surgery. This study included 120 patients aged 18-60 listed for spine fusion surgery...

Perioperative intravenous lidocaine in thoracoscopic surgery for improved postoperative pain control: a randomized, placebo-controlled, double-blind, superiority trial.

Hojski A, Bolliger D, Mallaev M , et al. · Journal of thoracic disease · 2024

Pain, including associated pain management, remains a burden on patients after thoracic surgery. Our objective was to investigate whether perioperative intravenous administration of lidocaine reduces...

A Systematic Review and Meta-analysis of the Analgesic Effects of Lidocaine Administered Intravenously or Intraperitoneally Post-Abdominal Surgery.

Bi Y, Diao M, Tao Y , et al. · Pain physician · 2024

Reducing postoperative pain is still a tremendous challenge for perioperative clinicians. Lidocaine is a local anesthetic that belongs to the amide class and has anti-inflammatory, anti-hyperalgesic,...

The analgesic effectiveness of perioperative lidocaine infusions for acute and chronic persistent postsurgical pain in patients undergoing breast cancer surgery: a systematic review and meta-analysis.

Hussain N, Brull R, Weber L , et al. · British journal of anaesthesia · 2024

Breast cancer is the most common cancer among women and tumour resection carries a high prevalence of chronic persistent postsurgical pain (CPSP). Perioperative i.v. lidocaine infusion has been propos...

Methadone in combination with magnesium, ketamine, lidocaine, and dexmedetomidine improves postoperative outcomes after coronary artery bypass grafting: an observational multicentre study.

Weinberg L, Johnston S, Fletcher L , et al. · Journal of cardiothoracic surgery · 2024

An optimal pharmacological strategy for fast-track cardiac anesthesia (FTCA) is unclear. This study evaluated the effectiveness and safety of an FTCA program using methadone and non-opioid adjuvant in...

Effects of intravenous lidocaine on postoperative pain and gastrointestinal function recovery following gastrointestinal surgery: a meta-analysis.

Dai Y, Huang J, Liu J · Minerva anestesiologica · 2024

The full extent of intravenous lidocaine's effectiveness in alleviating postoperative pain and enhancing gastrointestinal function recovery remains uncertain. We conducted an exhaustive search of data...

The effect of continuous bilateral parasternal block with lidocaine on patient-controlled analgesia opioid requirement and recovery after open heart surgery: a double-blind randomised controlled trial.

Larsson M, Sartipy U, Franco-Cereceda A , et al. · BJA open · 2024

We hypothesised that a continuous 72-h bilateral parasternal infusion of lidocaine at 2×35 mg h would decrease pain and the inflammatory response after sternotomy for open heart surgery, subsequently...

Use of IV Lidocaine Infusion Postoperatively Within the ERAS Surgical Population.

Norman S, Kubel K, Halterman R · Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses · 2024

The aim of this project was to investigate whether opioid pain scores, postoperative opioid requirements, and postanesthesia care unit (PACU) length of stay were impacted when comparing a 24-hour intr...

Effects of Intravenous Lidocaine on Quality of Recovery After Laparoscopic Bariatric Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Barbosa EC, Ortegal GHPC, Aguirre JM , et al. · Obesity surgery · 2024

This systematic review and meta-analysis aimed to assess the effects of pre and intraoperative lidocaine infusion on short-term recovery quality after laparoscopic bariatric surgeries. In the search a...

The use of lidocaine infusion in laparoscopic cholecystectomy: An updated systematic review and meta-analysis.

Awan B, Elsaigh M, Elkomos BE , et al. · Journal of minimal access surgery · 2024

Being one of the most common abdominal surgical procedures, numerous techniques have been adapted to decrease post-operative pain post cholecystectomy. However, the efficacy of intravenous (IV) lidoca...

Effect of intravenous lidocaine on outcomes in patients receiving propofol for gastrointestinal endoscopic procedures: an updated systematic review and meta-analysis.

Wu F, Zhan L, Xu W , et al. · European journal of clinical pharmacology · 2024

Gastrointestinal endoscopic procedures (GEPs) are frequently employed for the diagnosis and treatment of various gastrointestinal ailments. While propofol sedation is widely used during these procedur...

Postoperative use and early discontinuation of intravenous lidocaine in spine patients.

Soriano PBO, Haselhuhn JJ, Resch JC , et al. · Spine deformity · 2024

Our institution employs a multimodal approach to manage postoperative pain after spine surgery. It involves continuous intravenous (IV) lidocaine until the morning of postoperative day two. This study...

Letter re: "Perioperative Lidocaine Infusion Reduces Opioid Use in Enhanced Recovery After Surgery Patients Undergoing Laparoscopic Colectomy".

Yang WH, Xue FS, Li CW · The American surgeon · 2024

Postoperative analgesic effect of intravenous coinjection of lidocaine and dexmedetomidine in gynaecological surgery: a systematic review and meta-analysis.

Xie D, Wang F, Wen W , et al. · BMJ open · 2024

Hysterectomy or myomectomy is a common gynaecological procedure that results in moderate to severe acute postoperative pain, which can cause many adverse effects. This study aimed to compare the posto...

Benefit of intraoperative intravenous lidocaine on cognitive function following noncardiac surgery: An updated meta-analysis.

Chang YJ, Chang LC, Lan KM · Journal of clinical anesthesia · 2024

Efficacy of intraoperative systemic lidocaine on quality of recovery after laparoscopic colorectal surgery: a randomized controlled trial.

Lin W, Yang Y, Zhuo Y , et al. · Annals of medicine · 2024

Many clinical trials have demonstrated the benefits of intraoperative systemic lidocaine administration in major abdominal surgeries. We tested the hypothesis that systemic lidocaine is associated wit...

Lidocaine and risk of postoperative vomiting in children undergoing tonsillectomy: a randomised clinical trial.

Hu Y, Du MC, Chen Y , et al. · Scientific reports · 2024

The dose-response of intravenous lidocaine in preventing postoperative vomiting (POV) in children remains unclear. This study investigated whether intravenous lidocaine dose-dependently decreased POV...

Efficacy and safety of intravenous lidocaine infusion in postoperative pain management and surgical outcomes following laparoscopic colorectal surgery: A meta-analysis.

Mustafa MS, Shafique MA, Tabassum M , et al. · Current problems in surgery · 2024

Lidocaine effects on neutrophil extracellular trapping and angiogenesis biomarkers in postoperative breast cancer patients with different anesthesia methods: a prospective, randomized trial.

Zhang W, Liu J, Li X , et al. · BMC anesthesiology · 2024

Anesthesia techniques and drug selection may influence tumor recurrence and metastasis. Neutrophil extracellular trapping (NETosis), an immunological process, has been linked to an increased susceptib...

Author Correction: Effect of systemic lidocaine on postoperative quality of recovery, the gastrointestinal function, inflammatory cytokines of lumbar spinal stenosis surgery: a randomized trial.

Wu Y, Chen Z, Yao C , et al. · Scientific reports · 2024

Effects of perioperative intravenous lidocaine and esketamine on the quality of recovery and emotional state of patients after thyroidectomy: A randomised, double-blind, controlled trial.

Li M, Yang X, Zhu K , et al. · Indian journal of anaesthesia · 2024

Perioperative intravenous (IV) infusions of lidocaine and esketamine reduce postoperative pain, but there are few studies on the quality of recovery and patients' emotional states postoperatively. We...

Use of Perioperative Intravenous Lidocaine as Part of an Abdominal Surgery Enhanced Recovery Pathway Does Not Significantly Impact Postoperative Pain.

Althans AR, Kumpati B, Lavage DR , et al. · The American surgeon · 2024

The utility of perioperative intravenous lidocaine in improving postoperative pain control remains unclear. We aimed to compare postoperative pain outcomes in ERP abdominal surgery patients who did vs...

Intravenous lidocaine on postoperative pain and opioid consumption during gynecological surgery: a meta-analysis of randomized controlled trials.

Qin GC, Hu Y, Cha NH , et al. · Minerva obstetrics and gynecology · 2024

This study aimed to evaluate the role of intravenous lidocaine as a adjuvant anesthetics in patients undergoing gynecological surgery. We conducted a meta-analysis of randomized controlled trials (RCT...

Intravenous Lidocaine Compared with Quadratus Lumborum Block on Postoperative Analgesia Following Laparoscopic Renal Surgery: Protocol for a Randomized Noninferiority Trial.

Zhu GH, Hu JH, Zhuang MY , et al. · Journal of pain research · 2024

Patients undergoing laparoscopic renal surgery often experience significant postoperative pain. Quadratus lumborum block (QLB) provides effective postoperative pain control after laparoscopic procedur...

Safety of perioperative intravenous lidocaine in liver surgery - A pilot study.

Grassin P, Descamps R, Bourgine J , et al. · Journal of anaesthesiology, clinical pharmacology · 2024

Perioperative lidocaine infusion has many interesting properties such as analgesic effects in the context of enhanced recovery after surgery. However, its use is limited in liver surgery due to its he...

The effect of intravenous lidocaine on postoperative cognitive dysfunction: a systematic review and meta-analysis.

Geng C, Hu B, Jiang J , et al. · BMC anesthesiology · 2023

Postoperative cognitive dysfunction (POCD) has been reported as a significant complication in elderly patients. Various methods have been proposed for reducing the incidence and severity of POCD. Intr...

Perioperative Lidocaine Infusions and Pain Measurements: Effect Size Matters.

Nelson M, Pal N, Tran B · Anesthesia and analgesia · 2023

Effect of continuous post-operative lidocaine infusion in an enhanced recovery program on opioid use following gynecologic oncology surgery.

Taiym D, Cowan M, Nakamura B , et al. · Journal of gynecologic oncology · 2023

To determine the effectiveness of implementing an Enhanced Recovery After Surgery (ERAS) program, including continuous intraoperative and postoperative intravenous (IV) lidocaine infusion, on perioper...

Effect of systemic lidocaine on postoperative quality of recovery, the gastrointestinal function, inflammatory cytokines of lumbar spinal stenosis surgery: a randomized trial.

Wu Y, Chen Z, Yao C , et al. · Scientific reports · 2023

Surgery is one of the most frequent and effective intervention strategies for lumbar spinal stenosis, however, one-third of patients are not satisfied with postoperative outcomes. It is not clear whet...

Intraoperative intravenous infusion of lidocaine increases total and small vessel densities of sublingual microcirculation: a randomized prospective pilot study.

Grotowska M, Gozdzik W · The Journal of international medical research · 2023

Multiple organ failure can occur as a result of postoperative complications. Research has indicated that the underlying mechanism of organ dysfunction is a microcirculation disorder. Because of its an...

Serum lidocaine (lignocaine) concentrations during prolonged perioperative infusion in patients undergoing breast cancer surgery: A secondary analysis of a randomised controlled trial.

Toner AJ, Bailey MA, Schug SA , et al. · Anaesthesia and intensive care · 2023

Perioperative lidocaine (lignocaine) infusions are being employed with increasing frequency. The determinants of systemic lidocaine concentrations during prolonged administration are unclear. In the L...

Perioperative Lidocaine Infusion Reduces Opioid Use in Enhanced Recovery After Surgery Patients Undergoing Laparoscopic Colectomy.

Thomas GJ, Bauman JC, Bergeron S , et al. · The American surgeon · 2023

Enhanced Recovery After Surgery (ERAS) programs have become a mainstay of modern surgical care, and efforts to decrease postoperative opioid consumption have been increasingly employed. A previous stu...

Systemic Anti-Inflammatory Effects of Intravenous Lidocaine in Surgical Patients: A Systematic Review and Meta-Analysis.

Castro I, Carvalho P, Vale N , et al. · Journal of clinical medicine · 2023

There has recently been increasing evidence that the use of perioperative intravenous lidocaine infusion possesses analgesic, opioid-sparing and anti-inflammatory effects in surgical patients. Althoug...

Efficacy of intraoperative intravenous lidocaine infusion on postoperative opioid consumption after laparoscopic cholecystectomy: a randomized controlled trial.

Sarakatsianou C, Perivoliotis K, Baloyiannis I , et al. · Langenbeck's archives of surgery · 2023

We designed this study to evaluate the impact of intraoperative intravenous lidocaine infusion on postoperative opioid consumption after laparoscopic cholecystectomy. In total, 98 patients scheduled f...

The effect of lidocaine intraoperative infusion on quality of postoperative sleep in patients undergoing thyroidectomy: a randomized controlled trial.

Shao C, Lin L, Chen M , et al. · BMC anesthesiology · 2023

The incidence of thyroid nodules has increased significantly in recent years, and surgical removal is a common treatment. Postoperative sleep disturbance is still a serious problem in the current surg...

Effect of lidocaine or dexmedetomidine on postoperative recovery in elder patients undergoing colorectal surgery.

Qin P, Wei K, Yang Q , et al. · Minerva anestesiologica · 2023

Opioid sparing techniques have been shown to promote gastrointestinal recovery, shorten length of stay (LOS), and reduce opioid-related complications. We investigated whether intraoperative intravenou...

Perioperative intravenous lidocaine use in children.

Heath C, Hii J, Thalayasingam P , et al. · Paediatric anaesthesia · 2023

Perioperative pain management impacts patient morbidity, quality of life, and hospitalization cost. In children, it impacts not only the child, but the whole family. Adjuncts for improved perioperativ...

Efficacy of Lidocaine Infusion in High-Risk Vascular Surgery-A Randomized, Double-Blind, Placebo-Controlled Single-Center Clinical Trial.

Gajniak D, Mendrala K, Cyzowski T , et al. · Journal of clinical medicine · 2023

In perioperative pain control, adjuvants such as lidocaine can reduce opioid consumption in a specific type of surgery. The aim of this single-center prospective double-blinded randomized controlled t...

Appropriate Duration of Perioperative Intravenous Administration of Lidocaine to Provide Satisfactory Analgesia for Adult Patients Undergoing Colorectal Surgery: A Meta-Analysis of Randomized Controlled Trials.

Yang W, Yan S, Yu F , et al. · Anesthesia and analgesia · 2023

Perioperative lidocaine infusion has been reported to alleviate pain intensity after colorectal surgery. However, there is no consensus on whether prolonged lidocaine infusion is more effective than s...

The Influence of Intravenous Lidocaine Infusion on Postoperative Outcome and Neutrophil-to-Lymphocyte Ratio in Colorectal Cancer Patients. A Pilot Study.

Alexa AL, Ciocan A, Zaharie F , et al. · Journal of gastrointestinal and liver diseases : JGLD · 2023

In the last years increasing scientific evidence drew attention on the potential effects of anesthetic drugs on postoperative outcome in cancer patients. Local anesthetics, especially lidocaine, have...

A protocol for a pilot study to assess the feasibility of a randomised clinical trial of perioperative intravenous lidocaine on colorectal cancer outcome after surgery (FLICOR trial).

West R, Soo CP, Murphy J , et al. · BJA open · 2023

Cancer recurrence after curative cancer surgery significantly impacts patients and healthcare services. Before surgery, a small number of clinically undetectable circulating tumour cells are often pre...

The pharmacokinetics and safety of lidocaine in liver cancer patients undergoing hepatic resection.

He C, Jin Y, Zhang Y , et al. · European journal of clinical pharmacology · 2023

The purpose of this study was to explore the pharmacokinetics (PK) characteristics and safety of continuous lidocaine infusion during hepatectomy in liver cancer patients. This study included thirty-f...

Intravenous lidocaine improves postoperative cognition in patients undergoing laparoscopic colorectal surgery: a randomized, double-blind, controlled study.

Wang XX, Dai J, Wang Q , et al. · BMC anesthesiology · 2023

The risk of postoperative cognitive dysfunction(POCD) in laparoscopic surgery should not be overlooked. Intravenous lidocaine can reduce perioperative inflammatory response in patients undergoing lapa...

Efficacy of prolonged intravenous lidocaine infusion for postoperative movement-evoked pain following hepatectomy: a double-blinded, randomised, placebo-controlled trial.

Xu Y, Ye M, Liu F , et al. · British journal of anaesthesia · 2023

The analgesic effect of intravenous lidocaine varies with the duration of lidocaine infusion and surgery type. We tested the hypothesis that prolonged lidocaine infusion alleviates postoperative pain...

LidocAine Versus Opioids In MyocarDial infarction: the AVOID-2 randomized controlled trial.

Fernando H, Nehme Z, Milne C , et al. · European heart journal. Acute cardiovascular care · 2023

Opioid analgesia has been shown to interfere with the bioavailability of oral P2Y12 inhibitors prompting the search for safe and effective non-opioid analgesics to treat ischaemic chest pain. The lido...

Perioperative Intravenous Lidocaine Infusion for Postlaparoscopic Cholecystectomy Pain.

Shakir FTZ, Sultan R, Siddiqui R , et al. · Journal of the College of Physicians and Surgeons--Pakistan : JCPSP · 2023

To compare intravenous lidocaine infusion adjunct to NSAID and Acetaminophen with regular analgesics for postoperative mean pain score and mean ambulation time after laparoscopic cholecystectomy. Rand...

Lidocaine Intraoperative Infusion Pharmacokinetics during Partial Hepatectomy for Living Liver Donation.

Crouch CE, Wilkey BJ, Hendrickse A , et al. · Anesthesiology · 2023

Postoperative pain associated with open partial hepatectomy can be intense and persistent. The multimodal approach used to lessen this problem includes an intraoperative intravenous infusion of lidoca...

Intravenous lidocaine simultaneously infused with sufentanil to accelerate gastrointestinal function recovery in patients after thoracolumbar surgery: a prospective, randomized, double-blind controlled study.

Chen M, Wu D, Chen F , et al. · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023

Postoperative gastrointestinal dysfunction is one of the common complications of surgery, especially after surgery for a thoracolumbar spinal fracture. Intravenous lidocaine is a potential method to i...

Analgesic Effects and Adverse Reactions of Lidocaine for Patient-Controlled Intravenous Analgesia on Patients Undergoing Open Hepatectomy: A Retrospective Analysis.

Liu F, Xiong LL, Li TT , et al. · Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses · 2023

The aim of this study was to investigate the effect of lidocaine for patient controlled intravenous analgesia (PCIA) in patients who underwent open hepatectomy. A retrospective analysis. A total of 28...

Efficacy of intravenous lidocaine for post-laparoscopic cholecystectomy analgesia: A systematic review and meta-analysis.

Zhou T, Ju F, Zhang S , et al. · Asian journal of surgery · 2023

Effect of Intraoperative Intravenous Lidocaine on Postoperative Delirium in Elderly Patients with Hip Fracture: A Prospective Randomized Controlled Trial.

Li X, Wu J, Lan H , et al. · Drug design, development and therapy · 2023

This study was performed to evaluate the effects of intraoperative intravenous lidocaine on postoperative delirium in elderly patients with hip fracture. In total, 100 elderly patients undergoing hip...

Comparison of the Effects of Dexmedetomidine and Lidocaine on Stress Response and Postoperative Delirium of Older Patients Undergoing Thoracoscopic Surgery: A Randomized Controlled Trial.

Lai Y, Chen Q, Xiang C , et al. · Clinical interventions in aging · 2023

We investigated the effects of intraoperative intravenous lidocaine or dexmedetomidine infusion on inflammatory factors and cognitive function in patients undergoing thoracoscopic surgery. Patients ag...

Perioperative intravenous lidocaine for postoperative pain in patients undergoing breast surgery: a meta-analysis with trial sequential analysis of randomized controlled trials.

Li J, Huang J, Yang JT , et al. · Frontiers in oncology · 2023

The effectiveness of intravenous lidocaine infusion in managing acute and chronic pain following breast surgery has been a topic of debate. This meta-analysis aims to assess the impact of perioperativ...

Perioperative lidocaine and dexmedetomidine intravenous infusion reduce the serum levels of NETs and biomarkers of tumor metastasis in lung cancer patients: A prospective, single-center, double-blinded, randomized clinical trial.

Ren B, Cheng M, Liu C , et al. · Frontiers in oncology · 2023

Neutrophil extracellular traps (NETs) can enhance the metastasis of non-small cell lung cancer (NSCLC). As biomarkers of tumor metastasis, metalloproteinases (MMPs) and vascular endothelial growth fac...

Analgesic efficacy of Intraoperative lidocaine infusion in patients undergoing thyroidectomy.

Akgul E, Gozeler MS, Kars A , et al. · Revista da Associacao Medica Brasileira (1992) · 2023

A significant proportion of patients may experience moderate pain requiring treatment in the postoperative first 24 h following thyroidectomy. The aim of this study was to investigate the evaluation o...

Effect of co-administration of intravenous lidocaine and dexmedetomidine on the recovery from laparoscopic hysterectomy: a randomized controlled trial.

Xu S, Liu N, Yu X , et al. · Minerva anestesiologica · 2023

Some evidences have reported that intravenous lidocaine and dexmedetomidine alone can improve the quality of recovery after surgery. The main purpose of our study to explore whether co-administration...

Prophylactic effect of intravenous lidocaine against cognitive deficit after cardiac surgery: A PRISMA-compliant meta-analysis and trial sequential analysis.

Hung KC, Ho CN, Liu WC , et al. · Medicine · 2022

This study aimed at providing an updated evidence of the association between intraoperative lidocaine and risk of postcardiac surgery cognitive deficit. Randomized clinical trials (RCTs) investigating...

Effect of intravenous lidocaine on pain after head and neck cancer surgery (ELICO trial): A randomised controlled trial.

Wallon G, Erbacher J, Omar E , et al. · European journal of anaesthesiology · 2022

Treatment of postoperative pain after ear, nose and throat (ENT) cancer surgery is mainly morphine administration. Additional systemic lidocaine has shown promising results in some surgical procedures...

Intravenous Lidocaine Infusion Reduce Post-operative Pain and Length of Hospital in Elderly Patients Undergoing Surgery: Meta-analysis of Randomized Controlled Trials.

Zhu Y, Wang F, Yang L , et al. · Surgical innovation · 2022

It is debated wheter intravenous (IV) lidocaine improves post-operative pain and has other potential benefits in elderly patients. This systematic review and meta-analysis aimed to estimate the effect...

Efficacy of intravenous versus intraperitoneal lidocaine for postoperative analgesia in laparoscopic cholecystectomy: a randomized, double-blind, placebo-controlled trial.

Lapisatepun W, Nitayamekin A, Leurcharusamee P , et al. · Minerva anestesiologica · 2022

Laparoscopic cholecystectomy (LC) has become the gold standard for gallbladder removal due to the low degree of invasiveness. However, postoperative pain still persists. Local anesthetics provide anal...

Efficacy of systemic lidocaine in postoperative delirium in elderly patients undergoing laparoscopic colorectal surgery: study protocol for a multicentre, prospective, double-blind, randomised, parallel-group, superiority, placebo-controlled trial.

Liao X, Fu B, Yun J , et al. · BMJ open · 2022

Systemic lidocaine may reduce pain intensity and accelerate postoperative recovery. However, the efficacy of systemic lidocaine in cognitive function has not been established. This study protocol is d...

Intravenous Lidocaine for Postoperative Analgesia in 90 patients After Total Knee Arthroplasty and Limb Fractures.

Nallbani R, Komoni E, Sada F , et al. · Medical science monitor : international medical journal of experimental and clinical research · 2022

BACKGROUND The aim of this research was to investigate the analgesic effects of intravenous lidocaine on postoperative pain management in orthopedic patients after total joint arthroplasty and fractur...

Effect of intravenous lidocaine infusion on perioperative cellular immunity and the quality of postoperative recovery in breast cancer patients: a randomized controlled trial.

Wei Q, Xia M, Zhang Q , et al. · Gland surgery · 2022

Breast cancer has become the most common malignancy worldwide. Experimental and, retrospective, clinical data indicate that anaesthetic technique might influence the risk of metastasis after cancer su...

The Use of Intravenous Lidocaine in Perioperative Medicine: Anaesthetic, Analgesic and Immune-Modulatory Aspects.

Lee IW, Schraag S · Journal of clinical medicine · 2022

This narrative review provides an update on the applied pharmacology of lidocaine, its clinical scope in anaesthesia, novel concepts of analgesic and immune-modulatory effects as well as the current c...

Lidocaine Infusion for the Management of Postoperative Pain and Delirium (LIMPP): protocol for a randomised control trial.

Buren MA, Theologis A, Zuraek A , et al. · BMJ open · 2022

Postoperative delirium is a frequent adverse event following elective non-cardiac surgery. The occurrence of delirium increases the risk of functional impairment, placement to facilities other than ho...

Role of lidocaine and its effect on postoperative outcomes in abdominal cholecystectomy.

Afzal A, Syed AW, Mansoor Q , et al. · JPMA. The Journal of the Pakistan Medical Association · 2022

To investigate the role of pre- and intra-operative lidocaine infusion on post-operative pain management. The interventional, prospective study was conducted from September 2019 to June 2020 at the Pa...

Perioperative Dexmedetomidine or Lidocaine Infusion for the Prevention of Chronic Postoperative and Neuropathic Pain After Gynecological Surgery: A Randomized, Placebo-Controlled, Double-Blind Study.

Rekatsina M, Theodosopoulou P, Staikou C · Pain and therapy · 2022

The transition of acute to chronic postoperative pain (CPP) remains a significant burden to the rehabilitation of patients. The research for adjuvants to prevent CPP continues; among others, dexmedeto...

Effect of intravenous lidocaine on chronic postoperative pain in patients undergoing breast cancer surgery: a prospective, double-blind, randomized, placebo-controlled clinical trial.

Xia M, Wei Q, Zhang Q , et al. · Annals of translational medicine · 2022

Chronic postoperative pain (CPSP) is one of the common complications of breast cancer patients, which can seriously affect the quality of life and long-term prognosis of patients. The purpose of this...

The ALLEGRO trial: a placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery.

Paterson HM, Cotton S, Norrie J , et al. · Trials · 2022

Return of gastrointestinal (GI) function is fundamental to patient recovery after colorectal surgery and is required before patients can be discharged from hospital safely. Up to 40% of patients suffe...

Perioperative Intravenous Lidocaine Infusion for Postoperative Analgesia in Patients Undergoing Surgery of the Spine: Systematic Review and Meta-Analysis.

Licina A, Silvers A · Pain medicine (Malden, Mass.) · 2022

We conducted a systematic review and meta-analysis to examine the impact of perioperative intravenous lidocaine infusion on pain management scores, opioid consumption, adverse events, and hospital len...

Efficacy of intraoperative intravenous lidocaine for postoperative analgesia following bariatric surgery: a meta-analysis of randomized controlled studies.

Hung KC, Chang YJ, Chen IW , et al. · Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2022

The impact of intravenous lidocaine in adults undergoing laparoscopic bariatric surgeries (LBS) remains unclear. This study aimed at investigating the effect of intravenous lidocaine on postoperative...

Clinical Efficacy of Perioperative Intravenous Dexmedetomidine and Lidocaine Combined Infusion for Thyroidectomy: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.

Guo H, Ao T, Wang J , et al. · The Clinical journal of pain · 2022

The aim of this study was to evaluate the efficacy of perioperative dexmedetomidine (DEX) combined with lidocaine intravenous infusion on relieving postoperative pain and improving recovery for patien...

Efficacy of perioperative intravenous lidocaine infusion on postoperative pulmonary complications in patients undergoing video-assisted thoracoscopic lung resection surgery: protocol for a randomised controlled trial.

Wang F, He Y, Zhou M , et al. · BMJ open · 2022

Postoperative pulmonary complications (PPCs) are the most common complications following thoracoscopic surgery, resulting in increased hospital costs and perioperative mortality. Studies have shown th...

The evidence base for intra-articular lidocaine for closed manual reduction of acute anterior shoulder dislocation continues to grow.

Wakai A, Del Mar P · CJEM · 2022

Effects of Systemic Lidocaine Versus Dexmedetomidine on the Recovery Quality and Analgesia After Thyroid Cancer Surgery: A Randomized Controlled Trial.

Shu T, Xu S, Ju X , et al. · Pain and therapy · 2022

Surgical management is commonly used for thyroid cancer. We evaluated the effects of systemic lidocaine versus dexmedetomidine on the recovery quality and analgesia after thyroid cancer surgery. A tot...

Comparison of Ketamine, Dexmedetomidine and Lidocaine in Multimodal Analgesia Management Following Sleeve Gastrectomy Surgery: A Randomized Double-Blind Trial.

Ustun YB, Turunc E, Ozbalci GS , et al. · Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses · 2022

The aim of this study was to compare the effects of ketamine, dexmedetomidine, and lidocaine infusions added to the multimodal analgesia regimen on pain scores and analgesic requirement in laparoscopi...

Effects of propofol combined with lidocaine on hemodynamics, serum adrenocorticotropic hormone, interleukin-6, and cortisol in children.

Shi S, Gan L, Jin CN , et al. · World journal of clinical cases · 2022

Children are a unique patient population. Anesthesia for pediatric abdominal surgery has long been achieved mainly with intravenous amiodarone and propofol alone or combined with other anesthetics. Th...

Effect of lidocaine perioperative infusion on chronic postsurgical pain in patients undergoing thoracoscopic radical pneumonectomy.

Lu Y, Ding H, Shao C , et al. · BMC anesthesiology · 2022

Thoracoscopic radical pneumonectomy is associated with a high incidence of postoperative chronic pain. Studies on the benefits of lidocaine intravenous infusion during the perioperative period were st...

Intraoperative lidocaine infusion in patients undergoing pancreatectomy for pancreatic cancer: a mechanistic, multicentre randomised clinical trial.

Zhang H, Qu M, Guo K , et al. · British journal of anaesthesia · 2022

Intravenous lidocaine has been postulated to improve long-term survival after surgery for pancreatic cancer through anti-inflammatory effects, anti-tumour effects, or both. We investigated whether int...

Systemic lidocaine absorption from continuous erector spinae plane catheters after paediatric posterior spine fusion surgery.

Pan S, Lee CK, Caruso TJ , et al. · Regional anesthesia and pain medicine · 2022

Comparing Efficacy of Intravenous Dexmedetomidine and Lidocaine on Perioperative Analgesic Consumption in Patients Undergoing Laparoscopic Surgery.

Singh V, Pahade A, Mowar A · Anesthesia, essays and researches · 2022

Perioperative pain management is a major challenge for anaesthesiologists. IV lidocaine and dexmedetomidine have been utilised for peri-operative pain management. To analyse the effects of intraoperat...

Intravenous lidocaine versus dexamethasone to prevent postoperative vomiting in children tonsillectomy: a prospective randomized controlled trial.

Zouche I, Salem AB, Ketata S , et al. · The Pan African medical journal · 2022

we evaluate the effectiveness of lidocaine infusion compared to the intravenous dexamethasone and placebo on postoperative vomiting and first oral intake in children post tonsillectomy. we conducted a...

Effects of intra-operative infusion of lidocaine on postoperative pain and quality of recovery in patients undergoing gynecological laparoscopic surgery: A randomized controlled trial.

Awal S, Bhalotra AR, Sharma S · Journal of anaesthesiology, clinical pharmacology · 2022

Early recovery is desirable after day care surgery. Intravenous lidocaine has anti-inflammatory, anti-hyperalgesic, and analgesic effects and by reducing postoperative pain, nausea, vomiting, and dura...

Effects of Ketamine and Lidocaine Infusion on Acute Pain after Elective Open Abdominal Surgery, a Randomized, Double-Blinded Study.

Imani F, Bagheri AR, Arvin E , et al. · Medical journal of the Islamic Republic of Iran · 2022

Most patients suffer from moderate to severe pain after elective laparotomy. They often require opioids to alleviate their pain. Opiates invariably induce certain side effects and, occasionally, depen...

Lidocaine and Ketamine Infusions as Adjunctive Pain Management Therapy: A Retrospective Analysis of Clinical Outcomes in Hospitalized Patients Admitted for Pain Related to Sickle Cell Disease.

Zavala NA, Knoebel RW, Anitescu M · Frontiers in pain research (Lausanne, Switzerland) · 2022

In this study, we aim to evaluate the efficacy of adjunctive lidocaine and ketamine infusions for opioid reduction in the treatment of sickle cell disease in patients with vaso-occlusive crisis (VOC)....

Effect of Perioperative Intravenous Lidocaine on Postoperative Recovery in Patients Undergoing Ileostomy Closure: Study Protocol for a Randomized Controlled Trial.

Liu J, Liu K, Wang H , et al. · Journal of pain research · 2022

Opioids have been widely used clinically as the first choice for pain management. Ileostomy closure usually leads to temporary intestinal paralysis, which manifests as abdominal distension and pain, d...

Effect of Systemic Lidocaine on Postoperative Early Recovery Quality in Patients Undergoing Supratentorial Tumor Resection.

Zhao K, Dong Y, Su G , et al. · Drug design, development and therapy · 2022

Lidocaine has been gradually used in general anesthesia. This study was designed to investigate the effect of systemic lidocaine on postoperative quality of recovery (QoR) in patients undergoing supra...

Clinical Efficacy of Pulsed Radiofrequency Combined with Intravenous Lidocaine Infusion in the Treatment of Subacute Herpes Zoster Neuralgia.

Zhang W, He C · Pain research & management · 2022

Under the guidance of a digital subtraction angiography (DSA) machine, via fluoroscopic imaging techniques, patients diagnosed with herpes zoster neuralgia at the subacute stage, where self-reported p...

Lung-Protective Effects of Lidocaine Infusion on Patients with Intermediate/ High Risk of Postoperative Pulmonary Complications: A Double-Blind Randomized Controlled Trial.

Wang X, Guo K, Zhao Y , et al. · Drug design, development and therapy · 2022

The non-local anesthetic effects of lidocaine have been widely reported, but there are still few studies on lung protection. We aimed to test the hypothesis that intravenous infusion of lidocaine exer...

Effects of Lidocaine on Motor-Evoked Potentials and Somatosensory-Evoked Potentials in Patients Undergoing Intraspinal Tumour Resection: Study Protocol for a Prospective Randomized Controlled Trial.

Yue H, Zhou M, Chong Y , et al. · Journal of pain research · 2022

At present, it is believed that intravenous (IV) infusion of lidocaine can inhibit hyperalgesia, relieve postoperative acute and chronic pain, and accelerate the rehabilitation of patients. However, s...

Continuous Incisional Lidocaine in Pediatric Patients following Open Heart Surgery.

Fernández SN, Toledo B, Cebrián J , et al. · BioMed research international · 2022

Continuous incisional lidocaine infusion has been proposed as an adjunctive therapy in the management of postoperative pain in adult patients. The aim of this study was to determine the efficacy and s...

Intravenous lidocaine in spine surgery: A meta-analysis of randomized controlled trials.

Haratian A, Musa A, Field R , et al. · North American Spine Society journal · 2021

This study aimed to evaluate the role of intravenous lidocaine as a supplemental pain control modality in patients undergoing spine surgery. We conducted a meta-analysis of randomized controlled trial...

Perioperative Intravenous Lidocaine Infusion on Postoperative Recovery in Patients Undergoing Arthroscopic Rotator Cuff Repair Under General Anesthesia: A Randomized Controlled Trial.

Kim SJ, Choi YS, Chun YM , et al. · The Clinical journal of pain · 2021

Arthroscopic rotator cuff repair (ARCR) is known to cause severe postoperative pain that may interfere with recovery. Intravenous (IV) lidocaine has analgesic, anti-inflammatory, and antihyperalgesic...

A pilot multicentre randomised controlled trial of lidocaine infusion in women undergoing breast cancer surgery.

Toner AJ, Bailey MA, Schug SA , et al. · Anaesthesia · 2021

Chronic postoperative pain is common after breast cancer surgery. Peri-operative lidocaine infusion may prevent the development of chronic postoperative pain, but a large-scale trial is required to te...

Dexmedetomidine vs. lidocaine for postoperative analgesia in pediatric patients undergoing craniotomy: a protocol for a prospective, randomized, double-blinded, placebo-controlled trial.

Zhang Y, Bao D, Chi D , et al. · Trials · 2021

Postoperative pain is a common problem that occurs in pediatric patients following neurosurgery which may lead to severe complications. Dexmedetomidine is a commonly used adjuvant medicine in cranioto...

Effects of Intravenous Dexmedetomidine Versus Lidocaine on Postoperative Pain, Analgesic Consumption and Functional Recovery After Abdominal Gynecological Surgery: A Randomized Placebo-controlled Double Blind Study.

Rekatsina M, Theodosopoulou P, Staikou C · Pain physician · 2021

The management of acute postoperative pain remains challenging, and the search for adjuvants to reduce opioid use continues. We studied the effect of intravenous dexmedetomidine and lidocaine on posto...

Lidocaine for postoperative pain after cardiac surgery: a systematic review.

Boswell MR, Moman RN, Burtoft M , et al. · Journal of cardiothoracic surgery · 2021

Lidocaine is one of the most widely used local anesthetics with well-known pharmacological properties. The purpose of this systematic review is to investigate the effects of lidocaine on postoperative...

The use of intravenous lidocaine for postoperative pain and recovery: a reply.

Smith AF, Foo I · Anaesthesia · 2021

Use of intravenous lidocaine for postoperative pain and recovery.

Moyano J, Giraldo SP, Thola LM · Anaesthesia · 2021

The use of intravenous lidocaine for postoperative pain and recovery.

Dubowitz J, Toner A, Riedel B , et al. · Anaesthesia · 2021

Lidocaine combined with magnesium sulfate preserved hemodynamic stability during general anesthesia without prolonging neuromuscular blockade: a randomized, double-blind, controlled trial.

Paula-Garcia WN, Oliveira-Paula GH, de Boer HD , et al. · BMC anesthesiology · 2021

Lidocaine and magnesium sulfate have become increasingly utilized in general anesthesia. The present study evaluated the effects of these drugs, isolated or combined, on hemodynamic parameters as well...

Perioperative Lidocaine Infusion: Does the Risk Outweigh the Benefit?

Weinberg GL · Anesthesia and analgesia · 2021

The effect of intraoperative lidocaine infusion on postoperative opioid consumption in adolescents undergoing posterior spinal instrumentation and fusion for idiopathic scoliosis.

Lin R, Zhu K, Poznikoff AK , et al. · The spine journal : official journal of the North American Spine Society · 2021

Effects of intravenous lidocaine, dexmedetomidine, and their combination on IL-1, IL-6 and TNF-α in patients undergoing laparoscopic hysterectomy: a prospective, randomized controlled trial.

Xu S, Hu S, Ju X , et al. · BMC anesthesiology · 2021

Surgical-related inflammatory responses have negative effects on postoperative recovery. Intravenous (IV) lidocaine and dexmedetomidine inhibits the inflammatory response. We investigated whether the...

Efficacy of intravenous lidocaine infusions for pain relief in children undergoing laparoscopic appendectomy: a randomized controlled trial.

Kaszyński M, Lewandowska D, Sawicki P , et al. · BMC anesthesiology · 2021

Intravenous lidocaine, a potent local anesthetic with analgesic and anti-inflammatory properties, has been shown to be an effective adjunct that reduces intra- and postoperative opioid consumption and...

Effect of Intravenous Lidocaine Infusion on Postoperative Early Recovery Quality in Upper Airway Surgery.

Wang Q, Ding X, Huai D , et al. · The Laryngoscope · 2021

Systemic infusions of lidocaine have been widely used as perioperative analgesic adjuvants. The aim of this randomized, double-blinded, controlled trial was to investigate the effect of perioperative...

Intravenous Infusion of Lidocaine Can Accelerate Postoperative Early Recovery in Patients Undergoing Surgery for Obstructive Sleep Apnea.

Xie C, Wang Q, Huai D · Medical science monitor : international medical journal of experimental and clinical research · 2021

Obstructive sleep apnea (OSA) is defined by intermittent and recurrent episodes of partial or complete obstruction of the upper airway during sleep. Intermittent and recurrent hypoxia/reoxygenation is...

The Effect of Perioperative Lidocaine Infusion on Postoperative Pain and Postsurgical Recovery Parameters in Gynecologic Cancer Surgery.

Kutay Yazici K, Kaya M, Aksu B , et al. · The Clinical journal of pain · 2021

The primary objective of this prospective nonblinded randomized study was to investigate the effect of perioperative systemic lidocaine infusion on pain control after major gynecologic oncology surger...

The use of intravenous lidocaine for postoperative pain and recovery: international consensus statement on efficacy and safety.

Foo I, Macfarlane AJR, Srivastava D , et al. · Anaesthesia · 2021

Intravenous lidocaine is used widely for its effect on postoperative pain and recovery but it can be, and has been, fatal when used inappropriately and incorrectly. The risk-benefit ratio of i.v. lido...

Unlicensed intravenous lidocaine for postoperative pain: always a safer 'licence to stop' than to start.

Pandit JJ, McGuire N · Anaesthesia · 2021

Educating Nurses on Intravenous Lidocaine for Postoperative Pain Management.

Hunter OO, Wong A, Leng J , et al. · Pain management nursing : official journal of the American Society of Pain Management Nurses · 2021

As healthcare practitioners continue to search for multimodal analgesic therapies to reduce postoperative opioid requirements, surgical ward nurses need to stay up to date on the status of emerging th...

Effect of intra-operative intravenous lidocaine on opioid consumption after bariatric surgery: a prospective, randomised, blinded, placebo-controlled study.

Plass F, Nicolle C, Zamparini M , et al. · Anaesthesia · 2021

Peri-operative lidocaine infusion warrants investigation in bariatric surgery because obese patients present different physiological and pharmacological risks. This single-centre, prospective, randomi...

Association between perioperative intravenous lidocaine and subjective quality of recovery: A meta-analysis of randomized controlled trials.

Hung KC, Chu CC, Hsing CH , et al. · Journal of clinical anesthesia · 2021

To evaluate the impact of perioperative intravenous lidocaine on the quality of recovery (QoR) following surgery. Meta-analysis of randomized controlled trials (RCTs). Postoperative care. Intravenous...

Pre-, Peri-, and Postoperative Intravenous Ropivacaine versus that of Lidocaine for Analgesia after Hand-Assisted Laparoscopic Surgery of Left Colon Cancer: A Retrospective Analysis.

Gu X, Xiao C · Journal of investigative surgery : the official journal of the Academy of Surgical Research · 2021

Pre-, peri-, and postoperative intravenous lidocaine are reported effective in the management of postoperative pain in laparoscopic colorectal surgery but until the time, that of ropivacaine is not te...

Effect of perioperative intravenous lidocaine on postoperative outcomes in patients undergoing resection of colorectal cancer: a protocol for systematic review and meta-analysis.

Ji W, Zhang X, Sun G , et al. · BMJ open · 2021

Techniques using local anaesthetics provide high-quality analgesia, while the anti-inflammatory properties of these drugs may represent an additional advantage. Perioperative intravenous lidocaine has...

Effects of lidocaine, dexmedetomidine, and their combination infusion on postoperative nausea and vomiting following laparoscopic hysterectomy: a randomized controlled trial.

Xu S, Wang S, Hu S , et al. · BMC anesthesiology · 2021

A few studies have reported that administration of lidocaine and dexmedetomidine relieves the incidence of postoperative nausea and vomiting (PONV). We explored whether combined infusion of lidocaine...

The use of intravenous lidocaine for postoperative pain and recovery: a reply.

Foo I, Eipe N, Smith AF · Anaesthesia · 2021

The use of intravenous lidocaine for postoperative pain and recovery.

McKinney M · Anaesthesia · 2021

Efficacy of systemic lidocaine on postoperative quality of recovery and analgesia after video-assisted thoracic surgery: A randomized controlled trial.

Yao Y, Jiang J, Lin W , et al. · Journal of clinical anesthesia · 2021

Intraoperative systemic lidocaine has become widely accepted as an adjunct to general anesthesia, associated with opioid-sparing and enhanced recovery. We hypothesized that perioperative systemic lido...

The effect of systemic lidocaine on post-operative opioid consumption in ambulatory surgical patients: a meta-analysis of randomized controlled trials.

Lovett-Carter D, Kendall MC, Park J , et al. · Perioperative medicine (London, England) · 2021

Ambulatory surgical procedures continue to grow in relevance to perioperative medicine. Clinical studies have examined the use of systemic lidocaine as a component of multimodal analgesia in various s...

Intravenous Infusion of Lidocaine for Bowel Function Recovery After Major Colorectal Surgery: A Critical Appraisal Through Updated Meta-Analysis, Trial Sequential Analysis, Certainty of Evidence, and Meta-Regression.

Chen PC, Lai CH, Fang CJ , et al. · Frontiers in medicine · 2021

Intravenous infusion of lidocaine (IVF-Lido) during the perioperative period is an option to accelerate bowel function recovery after major colorectal surgery. However, previous meta-analyses have sho...

Efficacy of Perioperative Continuous Intravenous Lidocaine Infusion for 72 Hours on Postoperative Pain and Recovery in Patients Undergoing Hepatectomy: Study Protocol for a Prospective Randomized Controlled Trial.

Xu Y, Ye M, Hong Y , et al. · Journal of pain research · 2021

Many patients develop severe and persistent pain after hepatectomy delaying postoperative rehabilitation. Studies have suggested that intravenous lidocaine infusion relieved postoperative pain and imp...

Efficacy of Intravenous Use of Lidocaine in Postoperative Pain Management After Laparoscopic Colorectal Surgery: A Meta-analysis and Meta-regression of RCTs.

Sarakatsianou C, Perivoliotis K, Tzovaras G , et al. · In vivo (Athens, Greece) · 2021

Current literature reports regarding the effect of lidocaine in laparoscopic colectomies are still inconclusive. The purpose of this study was to review the current literature and estimate the overall...

Perioperative Intravenous Lidocaine and Metastatic Cancer Recurrence - A Narrative Review.

Wall TP, Buggy DJ · Frontiers in oncology · 2021

Cancer is a major global health problem and the second leading cause of death worldwide. When detected early, surgery provides a potentially curative intervention for many solid organ tumours. Unfortu...

Effect of Intravenous Lidocaine on Serum Interleukin-17 After Video-Assisted Thoracic Surgery for Non-Small-Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial.

Hou YH, Shi WC, Cai S , et al. · Drug design, development and therapy · 2021

Surgical stress promotes tumor metastasis. Interleukin (IL)-17 plays a pivotal role in cancer progression, and high IL-17 expression predicts poor prognosis of non-small-cell lung cancer (NSCLC). Lido...

Effect of intravenous lidocaine on short-term pain after hysteroscopy: a randomized clinical trial.

Peng X, Zhao Y, Xiao Y , et al. · Brazilian journal of anesthesiology (Elsevier) · 2021

The role of intravenous lidocaine infusion in endoscopic surgery has been previously evaluated for pain relief and recovery. Recently, it has been shown to reduce postoperative pain and opioid in pati...

Effects of Systemic Lidocaine on Postoperative Recovery Quality and Immune Function in Patients Undergoing Laparoscopic Radical Gastrectomy.

Lv X, Li X, Guo K , et al. · Drug design, development and therapy · 2021

This study aimed to explore the effects of lidocaine on postoperative quality of recovery (QoR) and immune function in patients undergoing laparoscopic radical gastrectomy. In total, 135 patients were...

Does intravenous lidocaine added to nonsteroidal anti-inflammatory drugs reduce pain during colposcopy? A prospective randomized double-blind study.

Topdaği YE, Topdagi Yilmaz EP, Aydin ME , et al. · Ginekologia polska · 2021

In recent years, lidocaine infusion for pain management during long operations is becoming more widespread in anesthesiology practice. However, only a limited number of studies have reported the intra...

The Effect of Lidocaine on Postoperative Quality of Recovery and Lung Protection of Patients Undergoing Thoracoscopic Radical Resection of Lung Cancer.

Wang L, Sun J, Zhang X , et al. · Drug design, development and therapy · 2021

To evaluate the effectiveness and safety of lidocaine on postoperative quality of recovery and lung protection of patients undergoing thoracoscopic radical resection of lung cancer. Seventy ASA II-III...

Intravenous Magnesium - Lidocaine - Ketorolac Cocktail for Postoperative Opioid Resistant Pain: A Case Series of Novel Rescue Therapy.

Zanza C, Longhitano Y, Lin E , et al. · Reviews on recent clinical trials · 2021

Severe postoperative pain is principally managed by opioids. While effective, opioids do not provide adequate relief in many patients and cause many side effects, including antinociceptive tolerance a...

Intravenous Lidocaine for Acute Pain: A Single-Institution Retrospective Study.

De Oliveira K, Eipe N · Drugs - real world outcomes · 2020

In the perioperative period, intravenous lidocaine has been used as an opioid-sparing systemic analgesic with additional anti-inflammatory and anti-hyperalgesic properties. The aim of this retrospecti...

The effect of preoperative intravenous lidocaine on postoperative pain following hysteroscopy: A randomized controlled trial.

Lee J, Lee S, Lee H , et al. · Medicine · 2020

The use of hysteroscopy for the diagnosis and treatment of uterine and endometrial abnormalities is often associated with postoperative pain. This randomized controlled trial aimed to assess the effic...

Intravenous Lidocaine Infusion for the Management of Early Postoperative Pain: A Comprehensive Review of Controlled Trials.

Chu R, Umukoro N, Greer T , et al. · Psychopharmacology bulletin · 2020

Previously used as anti-arrhythmic, intravenous lidocaine infusion is becoming popular for use in management of acute pain. There is still much to be understood about its pharmacokinetics and pharmaco...

Effect of perioperative intravenous lidocaine for patients undergoing spine surgery: A meta-analysis and systematic review.

Bi Y, Ye Y, Ma J , et al. · Medicine · 2020

Perioperative intravenous lidocaine has been reported to have analgesic and opioid-sparing effects in many kinds of surgery. Several studies have evaluated its use in the settings of spine surgery. Th...

Intravenous, Perioperatively Administered Lidocaine Regulates Serum Pain Modulators' Concentrations in Children Undergoing Spinal Surgery.

Kościelniak-Merak B, Batko I, Kobylarz K , et al. · Pain medicine (Malden, Mass.) · 2020

We analyzed the influence of perioperative, intravenous (i.v.) lidocaine infusion as a part of multimodal anesthesia on concentrations of selected pain modulators. An observational study. University C...

Is intravenous lidocaine protective against myocardial ischaemia and reperfusion injury after cardiac surgery?

Zhang C, Foo I · Annals of medicine and surgery (2012) · 2020

A best evidence topic was constructed using a described protocol. The three-part question addressed was: In patients undergoing cardiac surgery, does intravenous lidocaine exert a cardioprotective eff...

Neutrophil extracellular trapping and angiogenesis biomarkers after intravenous or inhalation anaesthesia with or without intravenous lidocaine for breast cancer surgery: a prospective, randomised trial.

Galoș EV, Tat TF, Popa R , et al. · British journal of anaesthesia · 2020

Experimental and, retrospective, clinical data indicate that anaesthetic technique might influence the risk of metastasis after cancer surgery. Neutrophil extracellular trapping (NETosis) is an immuno...

Perioperative intravenous lidocaine: Crossing local boundaries and reaching systemic horizons.

Kundra P, Vinayagam S · Indian journal of anaesthesia · 2020

A survey on the use of intravenous lidocaine infusion for acute pain in Scottish Hospitals.

Meaney ED, Reid L, Srivastava D · British journal of pain · 2020

Intravenous (IV) lidocaine infusions are increasingly used in the management of acute pain. They are particularly used in patients undergoing colorectal surgery, where they are also found to decrease...

Comparison of bupivacaine alone and in a combination with lidocaine for caudal block in patients undergoing circumcision: A historical cohort study.

Atasever AG, Ermiş O, Demir BŞ , et al. · Turkish journal of urology · 2020

Optimal analgesia following ambulatory surgery is an important matter in patient satisfaction, and it reduces unnecessary hospital admissions. This study investigated whether a caudal block with bupiv...

Intravenous lidocaine to prevent postoperative airway complications in adults: a systematic review and meta-analysis.

Yang SS, Wang NN, Postonogova T , et al. · British journal of anaesthesia · 2020

In surgical patients undergoing general anaesthesia, coughing at the time of extubation is common and can result in potentially dangerous complications. We performed a systematic review and meta-analy...

Synergistic effect of the association between lidocaine and magnesium sulfate on peri-operative pain after mastectomy: A randomised, double-blind trial.

Mendonça FT, Pellizzaro D, Grossi BJ , et al. · European journal of anaesthesiology · 2020

Recently, the use of venous adjuvants, such as lidocaine and magnesium sulfate, has been gaining ground in multimodal analgesia. However, no study has evaluated the impact a combination of the two dru...

Intravenous lidocaine to prevent endothelial dysfunction after major abdominal surgery: a randomized controlled pilot trial.

Pustetto M, Goldsztejn N, Touihri K , et al. · BMC anesthesiology · 2020

Major abdominal surgery is associated with endothelial glycocalyx disruption. The anti-inflammatory effects of lidocaine were recently associated with endothelial barrier protection. This was a single...

The effect of intraoperative lidocaine infusion on opioid consumption and pain after totally extraperitoneal laparoscopic inguinal hernioplasty: a randomized controlled trial.

Ghimire A, Subedi A, Bhattarai B , et al. · BMC anesthesiology · 2020

As a component of multimodal analgesia, the administration of systemic lidocaine is a well-known technique. We aimed to evaluate the efficacy of lidocaine infusion on postoperative pain-related outcom...

Lidocaine as an element of multimodal analgesic therapy in major spine surgical procedures in children: a prospective, randomized, double-blind study.

Batko I, Kościelniak-Merak B, Tomasik PJ , et al. · Pharmacological reports : PR · 2020

Introducing the principles of multimodal analgesic therapy is necessary to provide appropriate comfort for the patient after surgery. The main objective of the study was evaluating the influence of pe...

Prophylactic Effects of Intravenous Dexamethasone and Lidocaine on Attenuating Hemodynamic-Respiratory and Pain Complications in Children Undergoing Cleft Palate Repair Surgery With General Anesthesia.

Kheirabadi D, Shafa A, Hirmanpour A , et al. · Journal of pain & palliative care pharmacotherapy · 2020

This study aimed to compare the prophylactic effects of intravenous (IV) dexamethasone and lidocaine on hemodynamic condition, respiratory complications, pain control, and vomit incidence following cl...

Systemic lidocaine versus ultrasound-guided transversus abdominis plane block for postoperative analgesia: A comparative randomised study in bariatric surgical patients.

Gupta C, Valecha UK, Singh SP , et al. · Indian journal of anaesthesia · 2020

The multimodal analgesia strategies to minimise opioid-related side effects are highly desirable in bariatric surgical procedures. We evaluated the efficacy of ultrasound-guided transversus abdominis...

A survey of perioperative intravenous lidocaine use by anaesthetists in Australia and New Zealand.

Bailey MA, Toner AJ, Corcoran TB · Anaesthesia and intensive care · 2020

A randomised controlled trial of lidocaine infusion on post-operative opioid consumption in patients undergoing robotic colorectal surgery.

Herzog J, Schou M, Jensen KM , et al. · Danish medical journal · 2020

Intravenous lidocaine has been shown to have analgesic effects leading to a reduced post-operative opiate need, but this effect is still debated in various surgical populations. We investigated whethe...

Effect of intravenous, perioperative-administered lidocaine on serum levels of endocannabinoids and related N-acylethanolamines in children.

Kościelniak-Merak B, Batko I, Fleszar M , et al. · Minerva anestesiologica · 2020

Endocannabinoids and N-acylethanolamines (NAEs) are compounds that play a significant role in nociception. The promising therapeutic opportunities in postoperative pain management are connected with i...

Intravenous Lidocaine and Postoperative Cognition: Reply.

Klinger RY, Mathew JP · Anesthesiology · 2020

Intravenous Lidocaine and Postoperative Cognition: Comment.

Cao SJ, Zhu T · Anesthesiology · 2020

Utilization of Intravenous Lidocaine Infusion for the Treatment of Refractory Chronic Pain.

Tully J, Jung JW, Patel A , et al. · Anesthesiology and pain medicine · 2020

Chronic pain accounts for one of the most common reasons patients seek medical care. The financial burden of chronic pain on health care is seen by direct financial cost and resource utilization. Many...

Impact of perioperative intravenous lidocaine infusion on postoperative pain and rapid recovery of patients undergoing gastrointestinal tumor surgery: a randomized, double-blind trial.

Dai Y, Jiang R, Su W , et al. · Journal of gastrointestinal oncology · 2020

To explore the effect of perioperative intravenous lidocaine infusion on postoperative pain and the rapid recovery of patients undergoing gastrointestinal tumor surgery. The patients who underwent gas...

Effect of perioperative intravenous lidocaine on the incidence of short-term cognitive function after noncardiac surgery: A meta-analysis based on randomized controlled trials.

Huang X, Sun Y, Lin D , et al. · Brain and behavior · 2020

Postoperative cognitive dysfunction is a debilitating postoperative complication. The perioperative neuroprotective effect of lidocaine has conflicting results. In this qualitative review of randomize...

Intraoperative lidocaine infusion and 24-hour postoperative opioid consumption in obese patients undergoing laparoscopic bariatric surgery.

Tovikkai P, Rogers SJ, Cello JP , et al. · Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2020

Bariatric surgery is the most effective long-term treatment for obesity. Opioid-sparing anesthesia and multimodal analgesia such as lidocaine infusion have been recommended in these patients to reduce...

Association between intraoperative intravenous lidocaine infusion and survival in patients undergoing pancreatectomy for pancreatic cancer: a retrospective study.

Zhang H, Yang L, Zhu X , et al. · British journal of anaesthesia · 2020

Intravenous lidocaine has been shown to reduce opioid consumption and is associated with favourable outcomes after surgery. In this study, we explored whether intraoperative lidocaine reduces intraope...

The impact of peri-operative intravenous lidocaine on postoperative outcome after elective colorectal surgery: A meta-analysis of randomised controlled trials.

Rollins KE, Javanmard-Emamghissi H, Scott MJ , et al. · European journal of anaesthesiology · 2020

There has recently been increasing interest in the use of peri-operative intravenous lidocaine (IVL) due to its analgesic, anti-inflammatory and opioid-sparing effects. However, these potential benefi...

Postoperative analgesic efficacy of perioperative intravenous lidocaine infusion in patients undergoing septorhinoplasty: a prospective, randomized, double-blind study.

Ates İ, Aydin ME, Ahiskalioglu A , et al. · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2020

Intravenous lidocaine infusion has been used for postoperative analgesia in many surgical procedures in recent years. The aim of this randomized, double-blind study was to investigate the postoperativ...

Randomized, Double-Blind Study of the Effect of Intraoperative Intravenous Lidocaine on the Opioid Consumption and Criteria for Hospital Discharge After Bariatric Surgery.

Sakata RK, de Lima RC, Valadão JA , et al. · Obesity surgery · 2020

Surgical trauma, pain and opioids can cause nausea, vomiting, ileus and increased length of hospital stay. The primary objective of the study was to evaluate the time to recovery of gastrointestinal f...

The effects of intravenous lidocaine on wound pain and gastrointestinal function recovery after laparoscopic colorectal surgery.

Wei S, Yu-Han Z, Wei-Wei J , et al. · International wound journal · 2020

To evaluate the efficacy of intravenous lidocaine in relieving postoperative pain and promoting rehabilitation in laparoscopic colorectal surgery, we conducted this meta-analysis. The systematic searc...

Effect of Intravenous Lidocaine on Postoperative Pain in Patients Undergoing Intraspinal Tumor Resection: Study Protocol for a Prospective Randomized Controlled Trial.

Yue H, Zhou M, Lu Y , et al. · Journal of pain research · 2020

Patients undergoing intraspinal tumor resection usually experience severe acute pain, delaying postoperative rehabilitation, and increasing incidence of chronic pain. Recently, an increasing number of...

Effectiveness of intravenous lidocaine in preventing postoperative nausea and vomiting in pediatric patients: A systematic review and meta-analysis.

Nakajima D, Kawakami H, Mihara T , et al. · PloS one · 2020

Intravenous lidocaine in adults undergoing general anesthesia has been shown to reduce the incidence of postoperative nausea and vomiting (PONV). However, the anti-postoperative vomiting (POV) effect...

Systemic Lidocaine Infusion for Post-Operative Analgesia in Children Undergoing Laparoscopic Inguinal Hernia Repair: A Randomized Double-Blind Controlled Trial.

Lee HM, Choi KW, Byon HJ , et al. · Journal of clinical medicine · 2019

Systemic lidocaine can provide satisfactory post-operative analgesia in adults. In this study, we assessed whether intravenous lidocaine is effective for post-operative analgesia and recovery in child...

Effect of intraoperative paravertebral or intravenous lidocaine versus control during lung resection surgery on postoperative complications: A randomized controlled trial.

De la Gala F, Piñeiro P, Reyes A , et al. · Trials · 2019

Use of minimally invasive surgical techniques for lung resection surgery (LRS), such as video-assisted thoracoscopy (VATS), has increased in recent years. However, there is little information about th...

The effect of intraoperative lidocaine versus esmolol infusion on postoperative analgesia in laparoscopic cholecystectomy: a randomized clinical trial.

Bajracharya JL, Subedi A, Pokharel K , et al. · BMC anesthesiology · 2019

As a part of multimodal analgesia for laparoscopic cholecystectomy, both intraoperative lidocaine and esmolol facilitate postoperative analgesia. Our objective was to compare these two emerging strate...

Usage of Intravenous Lidocaine Infusion with Enhanced Recovery Pathway in Patients Scheduled for Open Radical Cystectomy: A Randomized Trial.

Moeen SM, Moeen AM · Pain physician · 2019

Intravenous lidocaine infusion (IVLI) reduces postoperative pain and hastens the return of bowel function. We aimed to compare the effects of adding lidocaine infusion to enhanced recovery pathway (ER...

Efficacy of systemic lidocaine to reduce chronic postsurgical pain: case not yet closed….

Kendall MC · Pain · 2019

Efficacy of intravenous lidocaine in improving post-operative nausea, vomiting and early recovery after laparoscopic gynaecological surgery.

Wang T, Liu H, Sun JH , et al. · Experimental and therapeutic medicine · 2019

Post-operative nausea and vomiting (PONV) is a major peri-operative complication. It has numerous adverse consequences that seriously affect the post-operative recovery of patients. The aim of the pre...

Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.

Klinger RY, Cooter M, Bisanar T , et al. · Anesthesiology · 2019

Cognitive decline after cardiac surgery occurs frequently and persists in a significant proportion of patients. Preclinical studies and human trials suggest that intravenous lidocaine may confer prote...

Meta-analysis of the effect of perioperative intravenous lidocaine on return of gastrointestinal function after colorectal surgery.

Cooke C, Kennedy ED, Foo I , et al. · Techniques in coloproctology · 2019

Return of normal gastrointestinal (GI) function is a critical determinant of recovery after colorectal surgery. The aim of this meta-analysis was to evaluate whether perioperative intravenous (IV) lid...

Continuous intravenous lidocaine infusion for postoperative pain and recovery in adults.

Paterson HM · Techniques in coloproctology · 2019

Perioperative Pregabalin and Intraoperative Lidocaine Infusion to Reduce Persistent Neuropathic Pain After Breast Cancer Surgery: A Multicenter, Factorial, Randomized, Controlled Pilot Trial.

Khan JS, Hodgson N, Choi S , et al. · The journal of pain · 2019

Persistent postsurgical pain is defined as pain localized to the area of surgery of a duration of ≥2 months and is, unfortunately, a common complication after breast cancer surgery. Although there is...

Evaluation of intravenous lidocaine in head and neck cancer surgery: study protocol for a randomized controlled trial.

Omar E, Wallon G, Bauer C , et al. · Trials · 2019

Pain after major head and neck cancer surgery is underestimated and has both nociceptive and neuropathic characteristics. Extended resection, flap coverage, nerve lesions, inflammation, and high-dose...

Effect of esmolol and lidocaine on agitation in awake phase of anesthesia among children: a double-blind, randomized clinical study.

Ji JY, Park JS, Kim JE , et al. · Chinese medical journal · 2019

Sevoflurane is widely used to anesthetize children because of its rapid action with minimal irritation of the airways. However, there is a high risk of agitation after emergence from anesthesia. Strab...

Impact of Intravenous, Perioperative-Administrated Lidocaine on Postoperative Serum Levels of Endogenous Opioids in Children.

Kościelniak-Merak B, Batko I, Kobylarz K , et al. · Current pharmaceutical design · 2019

Endogenous opioids are neuropeptides involved in pain-relieving processes. In the periphery, they are synthesised and stored in cells of the immune system. In the current study, we describe the influe...

Use of lidocaine to prevent postoperative coughing after partial laryngectomy: comparison of three delivery methods.

Wang Y, Lu WS, Qiao H , et al. · Drug design, development and therapy · 2019

To compare the effectiveness of lidocaine administration (intravenous injection, dripping via the tracheostomy tube, and spraying into the tracheostomy incision) on postoperative coughing after partia...

Intravenous lidocaine infusion as a component of multimodal analgesia for colorectal surgery-measurement of plasma levels.

Greenwood E, Nimmo S, Paterson H , et al. · Perioperative medicine (London, England) · 2019

Growing evidence suggests that intravenous lidocaine as a component of multimodal analgesia improves recovery after major colorectal surgery. There is little published data regarding ideal dosing and...

Safety and Tolerability of Lidocaine Infusions as a Component of Multimodal Postoperative Analgesia in Children.

Lemming K, Fang G, Buck ML · The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2019

Use of lidocaine as part of a multimodal approach to postoperative pain management has increased in adults; however, limited information is available regarding safety and tolerability in pediatrics. T...

Comparison of Perioperative Systemic Lidocaine or Systemic Ketamine in Acute Pain Management of Patients With Opioid Use Disorder After Orthopedic Surgery.

Sahmeddini MA, Khosravi MB, Farbood A · Journal of addiction medicine · 2019

Patients with opioid use disorder experience great challenges during acute pain management due to opioid tolerance or withdrawal symptoms. Previous studies have recommended the use of adjuvant drugs i...

Lidocaine infusions and preventative analgesia: can the answer to our prayers be hiding right under our noses?

Bicket MC, Cohen SP · Pain · 2018

Perioperative lidocaine infusions for the prevention of chronic postsurgical pain: a systematic review and meta-analysis of efficacy and safety.

Bailey M, Corcoran T, Schug S , et al. · Pain · 2018

Chronic postsurgical pain (CPSP) occurs in 12% of surgical populations and is a high priority for perioperative research. Systemic lidocaine may modulate several of the pathophysiological processes li...

Intravenously Administered Lidocaine and Magnesium During Thyroid Surgery in Female Patients for Better Quality of Recovery After Anesthesia.

Kim MH, Kim MS, Lee JH , et al. · Anesthesia and analgesia · 2018

Although systemic lidocaine and magnesium have been widely studied as perioperative analgesic adjuvants, they have been rarely evaluated with respect to recovery quality under the same conditions. We...

Quadratus Lumborum Block Versus Perioperative Intravenous Lidocaine for Postoperative Pain Control in Patients Undergoing Laparoscopic Colorectal Surgery: A Prospective, Randomized, Double-blind Controlled Clinical Trial.

Dewinter G, Coppens S, Van de Velde M , et al. · Annals of surgery · 2018

To investigate the comparative analgesic efficacy of systemic lidocaine and quadratus lumborum (QL) block in laparoscopic colorectal surgery. Although epidural analgesia is the standard to control pai...

Effect of intravenous lidocaine infusion on long-term postoperative pain after spinal fusion surgery.

Ibrahim A, Aly M, Farrag W · Medicine · 2018

Intravenous lidocaine infusion is known to reduce postoperative pain for days or weeks beyond the infusion time, and plasma half-life in several types of surgical procedures. To evaluate the effect of...

The Effect of Intraoperative Systemic Lidocaine on Postoperative Persistent Pain Using Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials Criteria Assessment Following Breast Cancer Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial.

Kendall MC, McCarthy RJ, Panaro S , et al. · Pain practice : the official journal of World Institute of Pain · 2018

To compare the incidence in postsurgical persistent pain following breast cancer surgery in women receiving intravenous lidocaine compared to saline using validated pain instruments in accordance with...

Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery in adults.

Weibel S, Jelting Y, Pace NL , et al. · The Cochrane database of systematic reviews · 2018

The management of postoperative pain and recovery is still unsatisfactory in a number of cases in clinical practice. Opioids used for postoperative analgesia are frequently associated with adverse eff...

Factors associated with intravenous lidocaine in pediatric patients undergoing laparoscopic appendectomy - a retrospective, single-centre experience.

Both CP, Thomas J, Bühler PK , et al. · BMC anesthesiology · 2018

Due to its potential beneficial effects, intra- and postoperative application of intravenous lidocaine has become increasingly accepted over the last couple of years, e.g. in patients undergoing lapar...

Intravenous lidocaine infusions for 48 hours in open colorectal surgery: a prospective, randomized, double-blinded, placebo-controlled trial.

Ho MLJ, Kerr SJ, Stevens J · Korean journal of anesthesiology · 2018

Although intravenous (i.v.) lidocaine is used as a perioperative analgesic in abdominal surgery, evidence of efficacy is limited. The infusion dose and duration remain unclear. This study aimed to inv...

Intravenous lidocaine infusion for pain control after laparoscopic cholecystectomy: A meta-analysis of randomized controlled trials.

Zhao JB, Li YL, Wang YM , et al. · Medicine · 2018

This meta-analysis aimed to assess the efficiency and safety of intravenous infusion of lidocaine for pain management after laparoscopic cholecystectomy (LC). A systematic search was performed in PubM...

Efficacy of intravenous lidocaine on pain relief in patients undergoing laparoscopic cholecystectomy: A meta-analysis from randomized controlled trials.

Li J, Wang G, Xu W , et al. · International journal of surgery (London, England) · 2018

Whether intravenous lidocaine has a beneficial role in controlling acute pain after a laparoscopic cholecystectomy (LC) in currently unknown. We performed a meta-analysis from randomized controlled tr...

Influence of dexmedetomidine and lidocaine on perioperative opioid consumption in laparoscopic intestine resection: a randomized controlled clinical trial.

Andjelković L, Novak-Jankovič V, Požar-Lukanovič N , et al. · The Journal of international medical research · 2018

The consumption of opioid analgesics could be reduced by the use of analgesics with different mechanisms of action. We investigated whether additional treatment with dexmedetomidine or lidocaine could...

Perioperative Use of Intravenous Lidocaine.

Beaussier M, Delbos A, Maurice-Szamburski A , et al. · Drugs · 2018

Lidocaine is an amide local anaesthetic initially used intravenously as an antiarrhythmic agent. At some point it was proposed that intravenous lidocaine (IVL) had an analgesic effect that could be po...

[Effects of Continuous Intravenous Intraoperative Lidocaine Infusion on Opioids Consumption and Postoperative Recovery in Patients Undergoing Video-assisted Thoracoscopic Lobectomy].

Liu ZJ, Zhang LY, Zheng XG , et al. · Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae · 2018

Objective To investigate whether continuous intravenous intraoperative lidocaine infusion can reduce the opioids dosage and improve postoperative recovery in patients undergoing video-assisted thoraco...

Lidocaine dose-response effect on postoperative cognitive deficit: meta-analysis and meta-regression.

Habibi MR, Habibi V, Habibi A , et al. · Expert review of clinical pharmacology · 2018

The true influence of the perioperative intravenous lidocaine on the development of postoperative cognitive deficit (POCD) in coronary artery bypass grafting (CABG) remains controversial. The principa...

[Effect of intravenous infusion with lidocaine on rapid recovery of laparoscopic cholecystectomy].

Chen XZ, Lou QB, Sun CC , et al. · Zhonghua yi xue za zhi · 2017

To investigate the effect of intravenous infusion with lidocaine on rapid recovery of laparoscopic cholecystectomy. This study was a prospective randomized controlled trial. From February to August 2...

Effect of Perioperative Intravenous Lidocaine Infusion on Acute and Chronic Pain after Breast Surgery: A Meta-Analysis of Randomized Controlled Trials.

Chang YC, Liu CL, Liu TP , et al. · Pain practice : the official journal of World Institute of Pain · 2017

Intravenous lidocaine infusion has been shown to reduce postoperative pain among patients undergoing abdominal surgery. This study aimed to evaluate the effects of perioperative lidocaine administrati...

Bolus administration of intravenous lidocaine reduces pain after an elective caesarean section: Findings from a randomised, double-blind, placebo-controlled trial.

Gholipour Baradari A, Firouzian A, Hasanzadeh Kiabi F , et al. · Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · 2017

We conducted a randomised double-blind, placebo-controlled trial to assess whether a bolus dose of lidocaine during the induction of general anaesthesia would reduce postoperative pain over 24 h. Leve...

Effects of intravenous lidocaine, dexmedetomidine and their combination on postoperative pain and bowel function recovery after abdominal hysterectomy.

Xu SQ, Li YH, Wang SB , et al. · Minerva anestesiologica · 2017

Intravenous (IV) lidocaine and dexmedetomidine have been shown to decrease postoperative pain, reduce analgesic consumption and facilitate return of bowel function. We investigated whether lidocaine c...

Retrospective case-control non-inferiority analysis of intravenous lidocaine in a colorectal surgery enhanced recovery program.

Naik BI, Tsang S, Knisely A , et al. · BMC anesthesiology · 2017

Enhanced recovery after surgery (ERAS) programs typically utilizes multi-modal analgesia to reduce perioperative opioid consumption. Systemic lidocaine is used in several of these ERAS algorithms and...

A randomized crossover study of the effects of lidocaine on motor- and sensory-evoked potentials during spinal surgery.

Urban MK, Fields K, Donegan SW , et al. · The spine journal : official journal of the North American Spine Society · 2017

Lidocaine has emerged as a useful adjuvant anesthetic agent for cases requiring intraoperative monitoring of motor-evoked potentials (MEPs) and somatosensory-evoked potentials (SSEPs). A previous retr...

Intravenous lidocaine for effective pain relief after bimaxillary surgery.

Lee U, Choi YJ, Choi GJ , et al. · Clinical oral investigations · 2017

The aim of this prospective, randomized, double-blind, placebo-controlled study was to evaluate the analgesic effect of intravenous lidocaine on postoperative pain in bimaxillary surgery. Between July...

Systemic lidocaine fails to improve postoperative morphine consumption, postoperative recovery and quality of life in patients undergoing posterior spinal arthrodesis. A double-blind, randomized, placebo-controlled trial.

Dewinter G, Moens P, Fieuws S , et al. · British journal of anaesthesia · 2017

It is inconclusive whether the perioperative administration of systemic lidocaine provides effective postoperative analgesia and enhances recovery in major orthopaedic surgery. We hypothesised that in...

Perioperative Use of Intravenous Lidocaine.

Dunn LK, Durieux ME · Anesthesiology · 2017

The Amide Local Anesthetic Lidocaine in Cancer Surgery-Potential Antimetastatic Effects and Preservation of Immune Cell Function? A Narrative Review.

Chamaraux-Tran TN, Piegeler T · Frontiers in medicine · 2017

Surgical removal of the primary tumor in solid cancer is an essential component of the treatment. However, the perioperative period can paradoxically lead to an increased risk of cancer recurrence. A...

Effects of systemic lidocaine versus magnesium administration on postoperative functional recovery and chronic pain in patients undergoing breast cancer surgery: A prospective, randomized, double-blind, comparative clinical trial.

Kim MH, Lee KY, Park S , et al. · PloS one · 2017

We aimed to compare the effects of intraoperative lidocaine and magnesium on postoperative functional recovery and chronic pain after mastectomy due to breast cancer. Systemic lidocaine and magnesium...

Peri-operative lidocaine infusion for open radical prostatectomy - a reply.

Weinberg L, Story D, Gordon I , et al. · Anaesthesia · 2016

Peri-operative lidocaine infusion for open radical prostatectomy.

Loadsman JA, McCulloch TJ, Paleologos MS , et al. · Anaesthesia · 2016

Lidocaine Reduces Acute Postoperative Pain After Supratentorial Tumor Surgery in the PACU: A Secondary Finding From a Randomized, Controlled Trial.

Peng Y, Zhang W, Kass IS , et al. · Journal of neurosurgical anesthesiology · 2016

Perioperative lidocaine infusion has been reported to reduce postoperative pain in patients after abdominal surgery; however, no study has examined lidocaine's effect on acute postoperative pain after...

Effect of intravenous lidocaine on the transcerebral inflammatory response during cardiac surgery: a randomized-controlled trial.

Klinger RY, Cooter M, Berger M , et al. · Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2016

Postoperative cognitive dysfunction (POCD) occurs frequently after cardiac surgery. The pathophysiology of POCD remains elusive, but previous work showed that intravenous lidocaine may be protective a...

Efficacy of Intravenous Lidocaine During Endoscopic Submucosal Dissection for Gastric Neoplasm: A Randomized, Double-Blind, Controlled Study.

Kim JE, Choi JB, Koo BN , et al. · Medicine · 2016

Endoscopic submucosal dissection (ESD) is an advanced therapy for early gastric neoplasm and requires sedation with adequate analgesia. Lidocaine is a short-acting local anesthetic, and intravenous li...

Efficacy and safety of intravenous lidocaine for postoperative analgesia and recovery after surgery: a systematic review with trial sequential analysis.

Weibel S, Jokinen J, Pace NL , et al. · British journal of anaesthesia · 2016

Improvement of postoperative pain and other perioperative outcomes remain a significant challenge and a matter of debate among perioperative clinicians. This systematic review aims to evaluate the eff...

Effect of a single dose of lidocaine and ketamine on intraoperative opioids requirements in patients undergoing elective gynecological laparotomies under general anesthesia. A randomized, placebo controlled pilot study.

García-Navia JT, Tornero López J, Egea-Guerrero JJ , et al. · Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria · 2016

Background and goal of study: there is evidence that perioperative intravenous ketamine and lidocaine reduce postoperative pain, postoperative opioids consumption, shortens hospital stay and accelerat...

Lidocaine Did Not Reduce Neuropsychological-Cognitive Decline in Patients 6 Months After Supratentorial Tumor Surgery: A Randomized, Controlled Trial.

Peng Y, Zhang W, Zhou X , et al. · Journal of neurosurgical anesthesiology · 2016

: There is equivocal evidence examining cognitive improvement in response to lidocaine during cardiac surgery; however, no study has examined its effect on postoperative neuropsychological-cognitive d...

[Effect of Subcutaneous Injection of Lidocaine in Zusanli (ST 36) and Jiaji (EX-B 2) Regions on Immune Function in Patients Undergoing Laparoscopic Cholecystectomy].

Meng XL, Qu Q · Zhen ci yan jiu = Acupuncture research · 2016

To observe the effect of acupoint injection of Lidocaine on serum IL-1β, TNF-α and T-lymphocyte subset activities in patients undergoing laparoscopic cholecystectomy (LC), so as to reveal its mechanis...

An estimation for an appropriate end time for an intraoperative intravenous lidocaine infusion in bowel surgery: a comparative meta-analysis.

Khan JS, Yousuf M, Victor JC , et al. · Journal of clinical anesthesia · 2016

There exists no commonly accepted regimen for an intravenous lidocaine infusion (IVLI). This study aims to determine an appropriate end time for an IVLI during bowel surgery. A systematic search for r...

Effect of endovenous lidocaine on analgesia and serum cytokines: double-blinded and randomized trial.

Ortiz MP, Godoy MC, Schlosser RS , et al. · Journal of clinical anesthesia · 2016

This trial aimed to compare postoperative analgesia, opioid consumption, duration of ileus and hospital stay, and cytokine levels in patients undergoing laparoscopic cholecystectomies who received int...

Clinical Efficacy of Intravenous Lidocaine for Thyroidectomy: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.

Choi GJ, Kang H, Ahn EJ , et al. · World journal of surgery · 2016

Systemic lidocaine has analgesic and anti-inflammatory effects. The purpose of this prospective, randomized, double-blind study was to evaluate the effects of intravenous lidocaine on pain following t...

A randomised controlled trial of peri-operative lidocaine infusions for open radical prostatectomy.

Weinberg L, Rachbuch C, Ting S , et al. · Anaesthesia · 2016

We allocated 76 men scheduled for radical retropubic prostatectomy to peri-operative lidocaine 2% or saline 0.9%: a pre-operative 0.075 ml.kg(-1) intravenous bolus; an intra-operative intravenous infu...

The analgesic efficacy of intravenous lidocaine infusion after laparoscopic fundoplication: a prospective, randomized, double-blind, placebo-controlled trial.

Dale GJ, Phillips S, Falk GL · Local and regional anesthesia · 2016

This study aimed to determine if intravenous lidocaine infusion reduces postoperative pain intensity following laparoscopic fundoplication surgery and to also validate the safety of intravenous lidoca...

Systemic Lidocaine Fails to Improve Postoperative Pain, But Reduces Time to Discharge Readiness in Patients Undergoing Laparoscopic Sterilization in Day-Case Surgery: A Double-Blind, Randomized, Placebo-Controlled Trial.

Dewinter GB, Teunkens A, Vermeulen K , et al. · Regional anesthesia and pain medicine · 2016

Perioperative systemic lidocaine provides postoperative analgesia, decreases opioid consumption, and facilitates rehabilitation in abdominal surgery. We hypothesized that systemic lidocaine has analge...

Autonomic hyperreflexia after spinal cord injury managed successfully with intravenous lidocaine: a case report.

Leão P, Figueiredo P · Patient safety in surgery · 2016

Some paraplegic patients may wish undergo some surgical procedures, like urological procedures, without anesthesia. However, these patients can develop autonomic hyperreflexia if cystoscopy is perform...

Effects of lidocaine and esmolol infusions on hemodynamic changes, analgesic requirement, and recovery in laparoscopic cholecystectomy operations.

Dogan SD, Ustun FE, Sener EB , et al. · Brazilian journal of anesthesiology (Elsevier) · 2016

We compared the effects of lidocaine and esmolol infusions on intraoperative hemodynamic changes, intraoperative and postoperative analgesic requirements, and recovery in laparoscopic cholecystectomy...

[Effects of lidocaine and esmolol infusions on hemodynamic changes, analgesic requirement, and recovery in laparoscopic cholecystectomy operations].

Dogan SD, Ustun FE, Sener EB , et al. · Revista brasileira de anestesiologia · 2016

We compared the effects of lidocaine and esmolol infusions on intraoperative hemodynamic changes, intraoperative and postoperative analgesic requirements, and recovery in laparoscopic cholecystectomy...

Efficacy of Intravenous Lidocaine for Postoperative Analgesia Following Laparoscopic Surgery: A Meta-Analysis.

Ventham NT, Kennedy ED, Brady RR , et al. · World journal of surgery · 2015

Intravenous (IV) lidocaine has analgesic and anti-inflammatory properties. This study aims to evaluate the efficacy of IV lidocaine in controlling postoperative pain following laparoscopic surgery. A...

Opiate refractory pain from an intestinal obstruction responsive to an intravenous lidocaine infusion.

Bafuma PJ, Nandi A, Weisberg M · The American journal of emergency medicine · 2015

A 24-year-old female patient presented to our community emergency department (ED) for abdominal pain that had progressively worsened over the last 28 hours. Of note, 1 month prior to her presentation,...

Comparison Between Intraperitoneal and Intravenous Lidocaine for Postoperative Analgesia After Elective Abdominal Hysterectomy, a Double-Blind Placebo Controlled Study.

Samimi S, Taheri A, Davari Tanha F · Journal of family & reproductive health · 2015

To compare the efficacy of intravenous and intraperitoneal injection of lidocaine and normal saline in relieving postoperative pain after elective abdominal hysterectomy. For this double-blind randomi...

Intraoperative intravenous lidocaine exerts a protective effect on cell-mediated immunity in patients undergoing radical hysterectomy.

Wang HL, Yan HD, Liu YY , et al. · Molecular medicine reports · 2015

Surgical procedures cause a decrease in lymphocyte proliferation rate, an increase in apoptosis and shifts the balance of T‑helper (Th)1/Th2 cells towards anti‑cell‑mediated immunity (CMI) Th2 dominan...

Neuroprotective effects of intravenous lidocaine on early postoperative cognitive dysfunction in elderly patients following spine surgery.

Chen K, Wei P, Zheng Q , et al. · Medical science monitor : international medical journal of experimental and clinical research · 2015

This study aimed to evaluate the effects of lidocaine treatment on cognitive impairment in aged patients undergoing spine surgery and to explore the underlying mechanism. Patients were randomly divide...

[Adjuvants in modern anesthesia - lidocaine].

Picardi S, Lirk P, Boeckh R , et al. · Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS · 2015

Local anesthetics (LA) are well known for their antinociceptive and antiarrhythmic properties, but exert alternative effects, i.e. anti-inflammatory activity, as well. These immunomodulatory propertie...

Intravenous lidocaine for effective pain relief after a laparoscopic colectomy: a prospective, randomized, double-blind, placebo-controlled study.

Ahn E, Kang H, Choi GJ , et al. · International surgery · 2015

A perioperative intravenous lidocaine infusion has been reported to decrease postoperative pain. The goal of this study was to evaluate the effectiveness of intravenous lidocaine in reducing postopera...

Does intravenous lidocaine infusion during video-assisted thoracoscopic surgery reduce postoperative analgesia? A randomized controlled study.

Slovack M, Taylor B, Bryce R , et al. · Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2015

Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery.

Kranke P, Jokinen J, Pace NL , et al. · The Cochrane database of systematic reviews · 2015

The management of postoperative pain and recovery is still unsatisfactory in clinical practice. Opioids used for postoperative analgesia are frequently associated with adverse effects including nausea...

In response to perioperative use of systemic lidocaine.

Tiouririne M, Terkawi AS, Durieux ME · Pain physician · 2015

Perioperative use of systemic lidocaine.

Sebastian MP, West S · Pain physician · 2015

Intravenous lidocaine for postmastectomy pain treatment: randomized, blind, placebo controlled clinical trial.

Couceiro TC, Lima LC, Burle LM , et al. · Brazilian journal of anesthesiology (Elsevier) · 2015

Postoperative pain treatment in mastectomy remains a major challenge despite the multimodal approach. The aim of this study was to investigate the analgesic effect of intravenous lidocaine in patients...

[Effect of intraoperative intravenous lidocaine on pain and plasma interleukin-6 in patients undergoing hysterectomy].

Oliveira CM, Sakata RK, Slullitel A , et al. · Revista brasileira de anestesiologia · 2015

Interleukin-6 (IL-6) is a predictor of trauma severity. The purpose of this study was to evaluate the effect of intravenous lidocaine on pain severity and plasma IL-6 after hysterectomy. A prospective...

[Intravenous lidocaine for post-mastectomy pain treatment: randomized, blind, placebo controlled clinical trial].

Couceiro TC, Lima LC, Burle LM , et al. · Revista brasileira de anestesiologia · 2015

Postoperative pain treatment in mastectomy remains a major challenge despite the multimodal approach. The aim of this study was to investigate the analgesic effect of intravenous lidocaine in patients...

A comparison among infusion of lidocaine and dexmedetomidine alone and in combination in subjects undergoing coronary artery bypass graft: a randomized trial.

Kim HJ, Kim WH, Kim G , et al. · Contemporary clinical trials · 2014

Previous studies have reported the cardioprotective effect of dexmedetomidine and lidocaine. We compared the effect of lidocaine and dexmedetomidine infusion during off-pump coronary artery bypass gra...

Is perioperative intravenous lidocaine for complex spine surgery a more complex issue?

Fry RA, Davis K · Anesthesiology · 2014

Safety, tolerability, and short-term efficacy of intravenous lidocaine infusions for the treatment of chronic pain in adolescents and young adults: a preliminary report.

Mooney JJ, Pagel PS, Kundu A · Pain medicine (Malden, Mass.) · 2014

To provide pediatric care providers with insight into lidocaine infusions for analgesia. This retrospective review was conducted to describe lidocaine infusions for chronic refractory pain within the...

Intraoperative systemic lidocaine for pre-emptive analgesics in subtotal gastrectomy: a prospective, randomized, double-blind, placebo-controlled study.

Yon JH, Choi GJ, Kang H , et al. · Canadian journal of surgery. Journal canadien de chirurgie · 2014

Pre-emptive intravenous lidocaine infusion is known to improve postoperative pain in abdominal surgery. We assessed the effect of intravenous lidocaine infusion in patients who underwent subtotal gast...

Systemic lidocaine to improve quality of recovery after laparoscopic bariatric surgery: a randomized double-blinded placebo-controlled trial.

De Oliveira GS, Duncan K, Fitzgerald P , et al. · Obesity surgery · 2014

Few multimodal strategies to minimize postoperative pain and improve recovery have been examined in morbidly obese patients undergoing laparoscopic bariatric surgery. The main objective of this study...

Systemic lidocaine in surgical procedures: effects beyond sodium channel blockade.

Brinkrolf P, Hahnenkamp K · Current opinion in anaesthesiology · 2014

This review presents current data on the systemic administration of lidocaine. The focus is on studies in the perioperative setting. In addition, there is a brief look at experimental data on the effe...

Intraoperative systemic infusion of lidocaine reduces postoperative pain after lumbar surgery: a double-blinded, randomized, placebo-controlled clinical trial.

Kim KT, Cho DC, Sung JK , et al. · The spine journal : official journal of the North American Spine Society · 2014

Analgesic effect of lidocaine infusion on postoperative pain. The aim of this study was to evaluate the analgesic effect of lidocaine infusion on postoperative pain after lumbar microdiscectomy. This...

Efficacy of intraperitoneal and intravenous lidocaine on pain relief after laparoscopic cholecystectomy.

Yang SY, Kang H, Choi GJ , et al. · The Journal of international medical research · 2014

This randomized, double-blind, placebo-controlled trial evaluated intraperitoneal (IP) lidocaine administration and intravenous (IV) lidocaine infusion for postoperative pain control after laparoscopi...

Intravenous lidocaine for post-operative pain relief after hand-assisted laparoscopic colon surgery: a randomized, placebo-controlled clinical trial.

Tikuišis R, Miliauskas P, Samalavičius NE , et al. · Techniques in coloproctology · 2014

Perioperative intravenous (IV) infusion of lidocaine has been shown to decrease post-operative pain, shorten time to return of bowel function, and reduce the length of hospital stay. This randomized,...

Effect of intravenous lidocaine on postoperative recovery of patients undergoing mastectomy: a double-blind, placebo-controlled randomized trial.

Terkawi AS, Durieux ME, Gottschalk A , et al. · Regional anesthesia and pain medicine · 2014

One of the modalities of treatment for breast cancer surgery pain is opioids, and opioids are associated with adverse effects such as itching and postoperative nausea and vomiting (PONV). Intravenous...

Systemic intravenous lidocaine for perioperative pain management: a call for changing indications in the package sheet.

Grassi P, Bregant GM, Crisman M · Heart, lung and vessels · 2014

Effect of perioperative intravenous lidocaine administration on pain, opioid consumption, and quality of life after complex spine surgery.

Farag E, Ghobrial M, Sessler DI , et al. · Anesthesiology · 2013

The authors tested the primary hypothesis that perioperative IV lidocaine administration during spine surgery (and in the postanesthesia care unit for no more than 8 h) decreases pain and/or opioid re...

Intravenous lidocaine for spine surgery pain control.

Chi JH · Neurosurgery · 2013

Pre- and intraoperative lidocaine injection for preemptive analgesics in laparoscopic gastrectomy: a prospective, randomized, double-blind, placebo-controlled study.

Kim TH, Kang H, Choi YS , et al. · Journal of laparoendoscopic & advanced surgical techniques. Part A · 2013

The preemptive intravenous injection of local anesthetics is known to improve postoperative pains in abdominal surgery. The aim of this study is to assess the effect of intravenous lidocaine injection...

Intraoperative intravenous lidocaine reduces hospital length of stay following open gastrectomy for stomach cancer in men.

Kang JG, Kim MH, Kim EH , et al. · Journal of clinical anesthesia · 2012

To evaluate whether intraoperative low-dose lidocaine infusion decreases postoperative analgesic consumption, ileus, and duration of hospital stay. Prospective, randomized, double-blinded trial. Opera...

Perioperative intravenous lidocaine decreases the incidence of persistent pain after breast surgery.

Grigoras A, Lee P, Sattar F , et al. · The Clinical journal of pain · 2012

Breast cancer surgery is associated with a high incidence of persistent postsurgical pain (PPSP). The aim of this study was to evaluate the impact of intravenous (IV) lidocaine on acute and PPSP, anal...

Perioperative systemic lidocaine for postoperative analgesia and recovery after abdominal surgery: a meta-analysis of randomized controlled trials.

Sun Y, Li T, Wang N , et al. · Diseases of the colon and rectum · 2012

Postoperative pain management remains a significant challenge after abdominal surgery. The aim of this meta-analysis was to evaluate the efficacy of systemic lidocaine for postoperative pain managemen...

The effect of perioperative intravenous lidocaine and ketamine on recovery after abdominal hysterectomy.

Grady MV, Mascha E, Sessler DI , et al. · Anesthesia and analgesia · 2012

Perioperative ketamine infusion reduces postoperative pain; perioperative lidocaine infusion reduces postoperative narcotic consumption, speeds recovery of intestinal function, improves postoperative...

[Proven and expected benefits of intravenous lidocaine administered during the perioperative period].

Giudice V, Lauwick S, Kaba A , et al. · Revue medicale de Liege · 2012

Local anesthetics which inhibit sodium channels are used for neural blockade during infiltration and locoregional anesthesia. Furthermore lidocaine given intravenously acts on other cellular systems a...

Effect of intraoperative intravenous lidocaine on postoperative pain and return of bowel function after laparoscopic abdominal gynecologic procedures.

Grady P, Clark N, Lenahan J , et al. · AANA journal · 2012

Abdominal surgery has a high incidence of postoperative pain and dysfunctional gastrointestinal motility. This study investigated the effect of a continuous intraoperative infusion of lidocaine on pat...

Systemic lidocaine to improve postoperative quality of recovery after ambulatory laparoscopic surgery.

De Oliveira GS, Fitzgerald P, Streicher LF , et al. · Anesthesia and analgesia · 2012

Perioperative systemic lidocaine has been shown to have beneficial postoperative analgesic effects. The only previous study examining the use of lidocaine in the outpatient setting did not detect an o...

Perioperative intravenous lidocaine infusion for postoperative pain control: a meta-analysis of randomized controlled trials.

Vigneault L, Turgeon AF, Côté D , et al. · Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2011

Various strategies have been proposed for postoperative pain control. Among those, intravenous lidocaine infusion (IVLI) has gained in interest. However, its clinical benefit remains unclear. This sys...

[Intravenous administration of lidocaine for perioperative analgesia. Review and recommendations for practical usage].

Herminghaus A, Wachowiak M, Wilhelm W , et al. · Der Anaesthesist · 2011

Lidocaine is commonly used for regional anesthesia and nerve blocks. However, recent clinical studies demonstrated that intravenous perioperative administration of lidocaine can lead to better postope...

Intravenous lidocaine for effective pain relief after inguinal herniorrhaphy: a prospective, randomized, double-blind, placebo-controlled study.

Kang H, Kim BG · The Journal of international medical research · 2011

This prospective, randomized, double-blind, placebo-controlled study evaluated the effectiveness of intravenous lidocaine to reduce post-operative pain in 64 inguinal herniorrhaphy patients. Intraveno...

Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.

Saadawy IM, Kaki AM, Abd El Latif AA , et al. · Acta anaesthesiologica Scandinavica · 2010

This double-blinded study aimed at evaluating and comparing the effects of magnesium and lidocaine on pain, analgesic requirements, bowel function, and quality of sleep in patients undergoing a laparo...

Impact of intravenous lidocaine infusion on postoperative analgesia and recovery from surgery: a systematic review of randomized controlled trials.

McCarthy GC, Megalla SA, Habib AS · Drugs · 2010

Postoperative pain continues to be inadequately managed. While opioids remain the mainstay for postoperative analgesia, their use can be associated with adverse effects, including ileus, which can pro...

Perioperative intravenous lidocaine infusion on postoperative pain relief in patients undergoing upper abdominal surgery.

Baral BK, Bhattarai BK, Rahman TR , et al. · Nepal Medical College journal : NMCJ · 2010

Due to unpleasant nature and physiological consequences of postoperative pain, search of safe and effective modalities for its management has remained a subject of interest to clinical researchers. An...

Intravenous lidocaine does not reduce length of hospital stay following abdominal hysterectomy.

Bryson GL, Charapov I, Krolczyk G , et al. · Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2010

Intravenous lidocaine given both intraoperatively and postoperatively decreases pain scores, reduces opioid consumption, and promotes faster return of bowel function following abdominal surgery. The p...

Intraoperative intravenous lidocaine.

de Oliveira CM, Issy AM, Sakata RK · Revista brasileira de anestesiologia · 2010

Most patients undergoing surgery experience moderate to severe pain, indicating the need to improve the anesthetic technique. Intravenous lidocaine has been widely used in the treatment of chronic pai...

The effect of perioperative intravenous lidocaine on postoperative pain and immune function.

Yardeni IZ, Beilin B, Mayburd E , et al. · Anesthesia and analgesia · 2009

Surgery-associated tissue injury leads to nociception and inflammatory reaction, accompanied by increased production of proinflammatory cytokines. These cytokines can induce peripheral and central sen...

Systemic lidocaine decreased the perioperative opioid analgesic requirements but failed to reduce discharge time after ambulatory surgery.

McKay A, Gottschalk A, Ploppa A , et al. · Anesthesia and analgesia · 2009

In this randomized, blinded, placebo-controlled trial, we evaluated whether systemic lidocaine would reduce pain and time to discharge in ambulatory surgery patients. Sixty-seven patients were enrolle...

Can intravenous lidocaine decrease postsurgical ileus and shorten hospital stay in elective bowel surgery? A pilot study and literature review.

Harvey KP, Adair JD, Isho M , et al. · American journal of surgery · 2009

This study examined whether systemic infusion of lidocaine, a local anesthetic with anti-inflammatory properties, can decrease surgical pain, length of postsurgical ileus, and hospital stay. Twenty-tw...

A randomized study of the effects of perioperative i.v. lidocaine on hemodynamic and hormonal responses for cesarean section.

El-Tahan MR, Warda OM, Diab DG , et al. · Journal of anesthesia · 2009

Intravenous infusion of lidocaine attenuates the stress response to surgery. We aimed to evaluate the effects of perioperative lidocaine on the hemodynamic and hormonal responses for cesarean delivery...

Intraoperative infusion of lidocaine reduces postoperative fentanyl requirements in patients undergoing laparoscopic cholecystectomy.

Lauwick S, Kim DJ, Michelagnoli G , et al. · Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2008

Lidocaine has been shown to inhibit neural conduction and to have anti-inflammatory properties. The purpose of this study was to determine whether intraoperative lidocaine infusion reduces opioid cons...

Meta-analysis of intravenous lidocaine and postoperative recovery after abdominal surgery.

Marret E, Rolin M, Beaussier M , et al. · The British journal of surgery · 2008

Continuous intravenous administration of lidocaine may decrease the duration of ileus and pain after abdominal surgery. Three databases (Medline, Embase and the Cochrane Controlled Trials Register) we...

Intra-articular lidocaine versus intravenous meperidine/diazepam in anterior shoulder dislocation: a randomised clinical trial.

Moharari RS, Khademhosseini P, Espandar R , et al. · Emergency medicine journal : EMJ · 2008

Anterior shoulder dislocation is one of the most common complaints of patients referred to emergency departments. Intravenous opiates and benzodiazepines are traditionally prescribed in order to relie...

Lack of impact of intravenous lidocaine on analgesia, functional recovery, and nociceptive pain threshold after total hip arthroplasty.

Martin F, Cherif K, Gentili ME , et al. · Anesthesiology · 2008

The analgesic effect of perioperative low doses of intravenous lidocaine has been demonstrated after abdominal surgery. This study aimed to evaluate whether a continuous intravenous low-dose lidocaine...

Lidocaine infusion as a rescue analgesic in the perioperative setting.

Clarke C, McConachie I, Banner R · Pain research & management · 2008

In the present case series, three patients for whom regional anesthesia may have been the optimum technique for controlling postoperative pain are discussed. However, due to prevailing circumstances,...

Intravenous lidocaine infusion facilitates acute rehabilitation after laparoscopic colectomy.

Kaba A, Laurent SR, Detroz BJ , et al. · Anesthesiology · 2007

Intravenous infusion of lidocaine decreases postoperative pain and speeds the return of bowel function. The authors therefore tested the hypothesis that perioperative lidocaine infusion facilitates ac...

Systemic lidocaine shortens length of hospital stay after colorectal surgery: a double-blinded, randomized, placebo-controlled trial.

Herroeder S, Pecher S, Schönherr ME , et al. · Annals of surgery · 2007

To characterize the beneficial effects of perioperative systemic lidocaine on length of hospital stay, gastrointestinal motility, and the inflammatory response after colorectal surgery. Surgery-induce...

The interaction effect of perioperative cotreatment with dextromethorphan and intravenous lidocaine on pain relief and recovery of bowel function after laparoscopic cholecystectomy.

Wu CT, Borel CO, Lee MS , et al. · Anesthesia and analgesia · 2005

Both dextromethorphan (DM) and IV lidocaine improve postoperative pain relief. In the present study, we evaluated the interaction of DM and IV lidocaine on pain management after laparoscopic cholecyst...

Perioperative intravenous lidocaine has preventive effects on postoperative pain and morphine consumption after major abdominal surgery.

Koppert W, Weigand M, Neumann F , et al. · Anesthesia and analgesia · 2004

Sodium channel blockers are approved for IV administration in the treatment of neuropathic pain states. Preclinical studies have suggested antihyperalgesic effects on the peripheral and central nervou...

Analgesic effects of intravenous lidocaine and morphine on postamputation pain: a randomized double-blind, active placebo-controlled, crossover trial.

Wu CL, Tella P, Staats PS , et al. · Anesthesiology · 2002

Phantom and stump pains, common sequelae of limb amputations, are significant impediments to rehabilitation of amputees. The pathophysiology and optimal treatment of postamputation pain states are unc...

Intraarterial lidocaine for pain control after uterine artery embolization for leiomyomata.

Keyoung JA, Levy EB, Roth AR , et al. · Journal of vascular and interventional radiology : JVIR · 2001

To evaluate the effectiveness of intraarterial lidocaine in controlling pain after uterine artery embolization (UAE). In this double-blind prospective study, patients undergoing UAE received preservat...

[The effect of continuous intra-articular and intra-bursal infusion of lidocaine on postoperative pain following shoulder arthroscopic surgery].

Niiyama Y, Omote K, Sumita S , et al. · Masui. The Japanese journal of anesthesiology · 2001

We evaluated the effects of continuous intra-articular and intra-bursal infusion of lidocaine on postoperative pain following shoulder arthroscopic surgery. Forty-one ASA I-II patients scheduled for s...

The effect of systemic lidocaine on pain and secondary hyperalgesia associated with the heat/capsaicin sensitization model in healthy volunteers.

Dirks J, Fabricius P, Petersen KL , et al. · Anesthesia and analgesia · 2000

Although effective in neuropathic pain, the efficacy of systemic lidocaine in non-neuropathic pain remains uncertain. We investigated the analgesic effect of systemic lidocaine on the heat/capsaicin s...

Preemptive effects of a combination of preoperative diclofenac, butorphanol, and lidocaine on postoperative pain management following orthognathic surgery.

Nagatsuka C, Ichinohe T, Kaneko Y · Anesthesia progress · 2000

The aim of the study was to investigate whether preemptive multimodal analgesia (diclofenac, butorphanol, and lidocaine) was obtained during sagittal split ramus osteotomy (SSRO). Following institutio...

Patient-controlled lidocaine analgesia for acromioplasty surgery.

Mallon WJ, Thomas CW · Journal of shoulder and elbow surgery · 2000

Twenty-four consecutive patients undergoing shoulder acromioplasty were given postoperative analgesia with a new method in which a patient-controlled continuous infusion of lidocaine infiltrated the s...

The use of preoperative lidocaine to prevent stridor and laryngospasm after tonsillectomy and adenoidectomy.

Koç C, Kocaman F, Aygenç E , et al. · Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 1998

The most important complications from tonsillectomy and adenoidectomy are bleeding, stridor, and laryngospasm. This controlled, double-blind study was designed to investigate the effects of topical an...

Intravenous lidocaine speeds the return of bowel function, decreases postoperative pain, and shortens hospital stay in patients undergoing radical retropubic prostatectomy.

Groudine SB, Fisher HA, Kaufman RP , et al. · Anesthesia and analgesia · 1998

Postoperative ileus is a concern among surgical patients. Epidural anesthesia and analgesia with local anesthetics can decrease the duration of ileus. Significant systemic absorption of local anesthes...

Equivalent outcomes during postoperative patient-controlled intravenous analgesia with lidocaine plus morphine versus morphine alone.

Cepeda MS, Delgado M, Ponce M , et al. · Anesthesia and analgesia · 1996

To evaluate a possible opioid-sparing effect of intravenous lidocaine we conducted a randomized, double-blind clinical trial. Patients undergoing intraabdominal surgery under general anesthesia were t...

Lidocaine and the inhibition of postoperative pain in coronary artery bypass patients.

Insler SR, O'Connor M, Samonte AF , et al. · Journal of cardiothoracic and vascular anesthesia · 1995

This study was designed to evaluate whether a continuous low-dose lidocaine infusion reduces postoperative pain and anxiety in patients undergoing coronary artery bypass grafting (CABG) and to retrosp...